Apr 12, 2024 · The Containment Strategy Guidelines that address novel and targeted MDROs, such as Candida auris and carbapenemase-producing Enterobacterales, Pseudomonas spp., and Acinetobacter are available on the Healthcare-Associated Infection (HAI) website.

Jul 12, 2024 · This guidance document provides recommendations to clinicians for treatment of infections caused by extended-spectrum β-lactamase producing Enterobacterales (ESBL-E), carbapenem-resistant Enterobacterales (CRE), and difficult-to-treat Pseudomonas aeruginosa (DTR-P. aeruginosa).

Oct 13, 2023 · Multidrug-resistant organisms (MDROs) are germs, often bacteria, that are resistant to one or more antimicrobial drugs. In most instances, MDRO infections have signs and symptoms similar to infections caused by microbes that can be treated with antimicrobial drugs; however, options for treating patients with MDRO infections are often extremely ...

Apr 11, 2024 · Extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales are resistant to common antibiotics and may require complex treatments. Infections caused by ESBL-producing Enterobacterales can occur both in and outside of healthcare settings.

Multidrug-resistant organisms (MDROs) are microorganisms, mainly bacteria, that are resistant to one or more classes of antimicrobial agents. 1 These include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococci species (VRE), carbapenemase-producing Enterobacteriaceae, and Gram-negative bacteria that produce exten...

Apr 12, 2024 · Two studies documented increased mortality, hospital lengths of stay, and hospital charges associated with multidrug-resistant gram-negative bacilli (MDR-GNBs), including an NICU outbreak of ESBL-producing Klebsiella pneumoniae (47) and the emergence of third- generation cephalosporin resistance in Enterobacter spp. in hospitalized adults (48).

•Understand what is an MDRO •Review antibiotics and bacterial resistance •Identify sources of MDRO’s •Review bacterial resistance mechanisms •Identify Current CDC MDRO threat levels •COVID-19 impact on U.S. MDRO’s •Review ESBL, CRE, CRAB and C.auris •Learn about next steps to mitigation

Extended spectrum beta-lactamase (ESBL) producing organisms are a group of bacteria that commonly cause infections both in healthcare settings and communities. They are primarily Enterobacterales such as Escherichia coli (E. coli) and Klebsiella pneumoniae.

Extended-spectrum β-lactamase (ESBL) enzymes are characterized by the ability to hydrolyze third-generation cephalosporins and aztreonam but are inhibited by clavulanic acid.

Excludes more common MDRO such as vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and extended-spectrum β-lactamase (ESBL)-producing organisms.