Targeting ERBB2 (HER2) Amplification Identified by Next …
Oct 21, 2019 · Human epidermal growth factor receptor 2 (HER2) is an effective therapeutic target in breast and gastric and gastroesophageal junction cancers. However, less is known …
Direct stimulation of ERBB2 highlights a novel cytostatic signaling ...
Oct 9, 2020 · In this paper, we found that antibodies (Abs) targeting different epitopes on the ERBB2 extracellular domain foster the activation of ERBB2 homodimers, and surprisingly …
ErbB2 resembles an autoinhibited invertebrate epidermal growth …
Aug 30, 2009 · Surface plasmon resonance (SPR) Secreted Spitz was immobilized on CM5 sensorchips by using amine coupling, exactly as described previously 13. Increasing …
Frontiers | ErbB2 Targeted Epigenetic Modulation: Anti-tumor …
Jan 23, 2020 · Binding of ST8176AA1 to ErbB2 receptor and internalization in tumor cells were investigated by enzyme-linked immunosorbent assay (ELISA), surface plasmon resonance …
Surface plasmon resonance immunosensor for ErbB2 breast …
Jan 28, 2016 · A highly sensitive surface plasmon resonance (SPR) immunosensor for the important ErbB2 breast cancer biomarker has been developed. Optimization of the assay has …
Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv
Oct 7, 2008 · We hypothesised that co-targeting the preferred ErbB2/ErbB3 heterodimer with a bispecific single-chain Fv (bs-scFv) antibody would promote increased targeting selectivity …
Therapeutic efficacy of anti-ErbB2 immunoliposomes
Aug 19, 2002 · F5 anti-ErbB2 immunoliposomes were immunoreactive as determined by surface plasmon resonance (SPR) and were avidly internalized by ErbB2-expressing tumor cell lines …
ErbB2: From an EGFR Relative to a Central Target for Cancer Therapy
Jun 30, 2016 · Currently, there are four FDA-approved therapeutics targeting ErbB2: the humanized antibodies trastuzumab, and pertuzumab, the kinase inhibitor lapatinib, and …
ERBB2 mRNA expression to distinguish HER2-low/neg breast …
May 31, 2023 · Background: Antibody-drug conjugates such as Trastuzumab deruxtecan significantly improved progression-free and overall survival for the HER2 low expression …
Regulation of ErbB2 localization and function in breast cancer cells …
Here, we demonstrate a novel functional interaction between ERM proteins and the ErbB2 receptor tyrosine kinase in breast cancer cells.