Epac2 is a target of cAMP, a major second messenger in various cells. Epac2 is coded by the RAPGEF4 gene, and is expressed mainly in brain, neuroendocrine, and endocrine tissues. [8] Epac2 functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation.

Epac (exchange protein activated by 3’-5’-cyclic adenosine monophosphate [cAMP]) has been investigated functionally and pathophysiologically as a potential therapeutic target of various diseases since it was identified in the late 90s as a novel cAMP target protein by …

EPAC2 inhibition compromised proapoptotic caspase adaptor protein (PACAP)-triggered astrocytic differentiation of neural precursor cells devoid of neuronal differentiation. Furthermore, EPAC2 over-secretion resulted in diminished MMP-2 protein levels through the EPAC2/MMP-2 signaling pathway.

Apr 30, 2020 · Activation as well as over-secretion of EPAC2 triggers apoptosis in neurons and EPAC-triggered apoptosis was intermediated via the modulation of Bcl-2 interacting member protein (BIM). EPAC2 secretory levels has proven to be more in low-grade clinical glioma than high-grade clinical glioma.

Jan 10, 2016 · Epac2 is a potential therapeutic target for treatment of type 2 diabetes. Epac (exchange protein activated by cyclic-AMP) 2 is a direct target of 3′-5′-cyclic adenosine monophosphate (cAMP) and is involved in cAMP-mediated signal transduction through activation of the Ras-like small GTPase Rap.

Epac1 (cAMP-GEF-1) and Epac2 (cAMP-GEF-II) are expressed in both mature and developing tissues. Recent studies have indicated that alterations in the cellular microenvironment are present in chronic degenerative inflammatory diseases and seem to affect the expression profile of Epac1 and Epac2.

Jun 21, 2021 · Herein, we demonstrated that EPAC2 plays a dominant role in regulating HMPV, AdV, and RSV infections. Treatment with MAY0132, an EPAC2-specific inhibitor, suppressed not only viral replication but also the induction of pro-inflammatory mediators in response to …

EPAC2 is a multi-domain protein with a molecular weight of ~116 kDa, containing a regulatory as well as catalytic components. 4,26 NH 2 -terminal forms the regulatory segment while COOH-terminal

Jan 10, 2016 · Epac2 is expressed mainly in brain, neuroendocrine and endocrine tissues, and is involved in diverse cellular functions in the tissues. In this review, we summarize the structure and function of Epac2.

Dec 3, 2021 · Epac‐2 activation significantly suppressed nuclear factor (NF)‐κB/mitogen‐activated protein kinase (MAPK) signalling in vivo and in vitro. Epac‐2 may be a therapeutic target for CD based on its anti‐inflammatory functions and protective effects on the intestinal barrier.