Maximal EMT scores of 4T1-SCC ranged from 0 to 80, demonstrating a high degree of retention of their epithelial phenotype. EMT scores of CTC1-SCC ranged from 380 to 400, proving the steady mesenchymal phenotype of the CTC1 subline.

Feb 7, 2024 · To investigate how E-cadherin regulates metastasis, we selected murine 4T1 breast carcinoma cells, a widely utilized model of stage IV metastatic breast cancer that retains E-cadherin expression.

Sep 4, 2024 · To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR.

Mar 29, 2019 · We show that despite their capacity to disseminate into secondary organs, 4T1 tumor models develop overt metastasis while EMT6-tumor bearing mice clear DTCs shed from primary tumors as well as...

Epithelial-mesenchymal transition (EMT) has been linked to metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability.

4T1 and EMT-6 are non-immunogenic, murine cell models for triple-negative breast cancer studies. Here, 4T1 are more aggressive and invasive tumour cells than EMT-6 with less invasive properties [2]. 4T07 is also a mouse cancer cell line.

Sep 1, 2024 · To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR.

Feb 2, 2024 · 18 evidence of overt EMT-like events of 4T1 cell metastasis. Taken together, these findings are 19 consistent with the highly aggressive phenotype in this widely utilized model of breast cancer 20 progression. Moreover, our findings help to …

Apr 4, 2011 · Here, we report that stable expression of miR-155 in 4T1 breast tumor cells reduces significantly the aggressiveness of tumor cell dissemination as a result of preventing...

MAFK promoted tumorigenic growth and metastasis by 4T1 cells when implanted subcutaneously in mice. Overexpression of MAFK in mouse breast epithelial NMuMG cells induced epithelial-mesenchymal transition (EMT) phenotypes and promoted tumor formation and invasion in mice.