EGFR blocks ALKBH5 nuclear export, increasing m6A eraser function and suppression of ferroptosis through glutathione production. ALKBH5 inhibitors enhance the anti-tumor efficacy …

Here, we show that epidermal growth factor receptor (EGFR) signaling repressed N6-methyladenosine (m6A) levels in glioblastoma stem cells (GSCs), whereas ge-netic or …

The mechanism involved METTL3 m6A methylation of epidermal growth factor (EGF) which increased EGF translation via interaction with m6A reader YTHDC1. In turn, EGF increased …

Mechanically, we demonstrated that inhibition of METTL3 impaired HR efficiency and increased ADR-induced DNA damage by regulating m6A modification of EGF/RAD51 axis. METTL3 …

May 3, 2022 · Mechanically, we demonstrated that inhibition of METTL3 impaired HR efficiency and increased ADR-induced DNA damage by regulating m6A modification of EGF/RAD51 axis.

YTHDC1 binds to m6A-modified EGF mRNA and promotes EGF synthesis, suggesting that METTL3 and YTHDC1 together enhance HR and cell survival during doxorubicin treatment, …

Dec 15, 2023 · These results suggest that YTHDC1 protects cells from stress-induced senescence independent of m6A pathway, and the effect of METTL3 deletion is consistent …

Apr 25, 2024 · The m6A modification facilitated by METTL3 stimulates the expression of EGF, which in turn elevates the expression of RAD51, resulting in increased HR activity and …

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation

May 3, 2022 · Biochemical approaches and cellular experiments show a novel effect of METTL3 on homologous recombination repair and chemotherapeutic response via the m6A-YTHDC1 …