Dec 5, 2024 · MYOD is an E-box sequence-specific basic Helix-Loop-Helix (bHLH) transcriptional activator that, when expressed in non-muscle cells, induces nuclear reprogramming toward …

In this study, we demonstrate that protein engineering of the master transcription factor MyoD can enhance the conversion of human dermal fibroblasts and adult stem cells to a skeletal …

Here we show that calcineurin/NFAT (nuclear factor of activated T cells) signaling is required for primary myogenesis by transcriptional cooperation with the basic helix-loop-helix transcription …

Aug 8, 2018 · Here, by an integrative analysis of MyoD cistrome combined with genome-wide analysis of key regulatory histones and gene expression data we show that the affinity …

Dec 30, 2011 · In this study, we provide in vivo and in vitro evidence that the CE is necessary for circadian expression of MyoD in adult muscle. Gel shift assays identified a conserved non …

Dec 11, 2013 · MYOD expression in hAFS cells successfully induced differentiation into multinucleated myotube-like cells. Consistently, significant expression of myogenic marker …

The MyoD iCre allele allows highly efficient labeling of embryonic and fetal myoblasts, as well as satellite cell progenitors, and is not expressed outside of myogenic populations in the embryo …

Oct 16, 2007 · The MyoD basic region is the binding site for both E-box and tetraplex DNA. Homodimeric MyoD associates more tightly with tetraplex forms of regulatory sequences of …

Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the …

Jan 26, 2006 · Our findings indicate that Myod and Myog have distinct regulatory roles at a similar set of target genes. At genes expressed throughout the program of myogenic differentiation, …