EEA1 is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late endosomes and for sorting at the early endosome level. [5] [6] EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes. [7]

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Jun 2, 1995 · We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated with early endosomes since it co-localizes by immunofluorescence with the transferrin receptor and with Rab5 but not with Rab7.

EEA1, a 162-kDa autoantigen associated with subacute cutaneous systemic lupus erythematosus, has been shown to be specifically associated with the cytoplasmic face of the early endosome membrane (Mu et al., 1995).

Mar 28, 2025 · EEA1 (Early Endosome Antigen 1) is a Protein Coding gene. Diseases associated with EEA1 include Subacute Cutaneous Lupus Erythematosus and Cutaneous Lupus Erythematosus. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Innate Immune System.

We have cloned a human cDNA encoding an evolutionarily conserved 180-kDa protein on early endosomes named EEA1 (Early Endosome Antigen1). EEA1 is associated with early endosomes since it co-localizes by immunofluorescence with the transferrin receptor and with Rab5 but …

EEA1, an early-endosomal protein originally identified as an autoantigen, is essential for endocytic membrane fusion. It interacts with early endosomes via binding to the membrane lipid phosphatidylinositol 3-phosphate (PtdIns3P) and the active form of the small GTPase Rab5.

Mar 5, 2024 · Data indicate that early endosome antigen 1 (EEA1) is important for the small GTPase Rab31-mediated enhancement of ligand-bound EGF receptor (EGFR) endocytic trafficking.

Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Showing features for binding site. Gene Ontology (GO) annotations organized by slimming set.