The extracellular matrix (ECM), constituting over 70% of the skin, is the central hub for repair and regeneration of the skin. As such, the ECM is the area where changes related to photodamage are most evident.

In skin, cell-ECM interactions influence normal homeostasis, aging, wound healing, and disease. Disturbed integrin and ECM signaling contributes to both tumor formation and fibrosis.

Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health.

Aug 1, 2022 · In this review, we focus on the role of ECM molecules produced by dermal fibroblasts in skin development, homeostasis and wound healing, and we also discuss how disruption of ECM homeostasis may trigger the pathogenesis of skin diseases associated with abnormal wound healing response, such as chronic wounds, and the skin fibrotic disease keloid.

May 10, 2021 · Our study highlights the significance of BM heterogeneity in distinct inter-tissue interactions. The extracellular matrix (ECM) is a complex noncellular network of multicellular organisms...

The time-resolved ECM atlas constructed in this study identifies the ECM components with different types in tollder, teenager, adult and elderly, providing a new standard of age-specific skin ECM composition to discover new clues regarding tissue engineering for skin regeneration.

Nov 1, 2020 · Human skin is composed of the cell-rich epidermis, the extracellular matrix (ECM) rich dermis, and the hypodermis. Within the dermis, a dense network of ECM proteins provides structural support to the skin and regulates a wide variety of signaling pathways which govern cell proliferation and other critical processes.

Nov 26, 2021 · We found that the collagens, glycoproteins, proteoglycans, and regulatory factors that support skin development and interact with these core ECM proteins were differentially expressed at different ages. ECM expression markers occurring during the process of skin development were identified.

Mar 19, 2020 · The extracellular matrix (ECM) occupies the space between cell and cell, and serves as a sort of intranet which connects the whole organism. Current research is focused on the ECM and, it is now possible to develop increasingly effective strategies for the prevention and treatment of degenerative diseases and even, cutaneous ageing.

May 9, 2023 · By making smart skin care choices and following a consistent routine, you can help support the ECM as you age and help keep your skin looking and feeling younger, longer.