In biology, the extracellular matrix (ECM), [1][2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells. [3][4][5] Because multicellularity evolved independently...

The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. Components of the ECM link together to form a structurally stable composite, contributing to the mechanical properties of tissues.

Sep 8, 2017 · The extracellular matrix directs the morphology of a tissue by interacting with cell-surface receptors and by binding to the surrounding growth factors that then incite signaling pathways. In fact, the extracellular matrix actually stores some cellular growth factors, which are then released locally based on the physiological needs of the local ...

Feb 27, 2023 · Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours, including differentiation, migration and proliferation, through mechanotransduction. Studies of...

Jun 27, 2024 · We find that ECM remodeling alters mitochondrial homeostasis in an evolutionarily conserved manner. Mechanistically, ECM remodeling triggers a TGF-β response to induce mitochondrial fission and the unfolded protein response of the mitochondria (UPR MT).

The extracellular matrix (ECM) is responsible for the physical maintenance 1 of all cells. However, the concept that the ECM has a passive role to play in cellular activity has been refuted.

The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and homeostasis.

Oct 22, 2014 · Cells control ECM mechanics through degradation, synthesis, organization and pre-stress of its components. Mechanical cues from the ECM trigger signalling cascades that alter gene expression and...

This course teaches the effects of mechanical forces (strains) on cells and how cells generate mechanical forces by their contraction. Critical to both topics is the mechanical behavior of the extracellular matrix (ECM), which the cells have synthesized and remodeled. The ECM affects cell behavior by mediating exogenous mechanical strains, which stimulate certain cellular processes.

The extracellular matrix (ECM) acts as an adhesive that holds all the cells of a tissue in place. It also forms a few specialized structures such as cartilage, tendons, and the basement membrane (also called the basal lamina).