EGFR inhibition reversed E2F1 activity in vivo, whereas E2F1 inhibition suppressed POMC and ACTH in cultured human pituitary tumor cells. The corti-EGFR-Tg phenotype recapitulates ACTH-secreting pituitary adenomas and Cushing disease, validating the relevance of EGFR to corticotroph tumorigenesis.

Upon signal activation, EGFR accumulates in the nucleus facilitated by binding with transcription factors E2F1 and STAT3 through importins, leading to up-regulation of B-Myb, iNOS and Cyclin D1.

Aug 4, 2017 · In addition, we identified the epidermal growth factor receptor (EGFR) as a direct target of E2F1 and demonstrated that inhibition of receptor signaling abrogates E2F1-induced invasiveness 9....

E2F1 is a strong inducer of apoptosis in response to DNA damage through its capacity to activate p53/p73 death pathways. Recent evidence, however, showed that E2F1, which is aberrantly expressed in advanced malignant melanomas together with antagonistic p73 family members, drives cancer progression.

We demonstrated a molecular mechanism whereby WNT5A be negatively regulated by transcription factor E2F1, and ERK1/2 inhibitor (U0126) suppressed E2F1's regulation of WNT5A expression in EGFR-mutant cells.

Jan 30, 2007 · The discovery that the EGFR-Ras pathway inhibits E2F1-induced apoptosis in flies has potentially important implications for future cancer therapy. Pharmaceutical attenuation of signaling pathways that inhibit E2F1-induced apoptosis may lead to selective killing of tumor cells that lack functional RB but retain operational apoptotic machinery ...

Jan 1, 2006 · Via the ability of nuclear EGFR to associate with STAT3 and E2F1 and to upregulate expression of cyclin D1, iNOS and B-Myb, a new link is established that associates EGFR with several cellular processes such as cell cycle progression and nitric oxide pathway.

Mar 8, 2025 · Our findings uncovered the oncogenic role of SKA3 in LUAD progression and elucidated a novel EGFR/E2F1/SKA3/integrin β1 signaling loop, providing a potential SKA3-directed therapeutic strategy for LUAD patients.

Jan 30, 2007 · A recent study reveals epidermal growth factor receptor (EGFR) signaling to be one such variable, as EGFR signaling cooperates with RB in inhibiting E2F1-induced apoptosis.

Jul 24, 2014 · Here we show that one of the functions of miR-998 is to suppress dE2F1-dependent cell death specifically in rbf mutants by elevating EGFR signaling. Mechanistically, miR-998 operates by repressing dCbl, a negative regulator of EGFR signaling.