E2F1 binds preferentially RB1 in a cell-cycle dependent manner (PubMed: 10675335, PubMed: 12717439, PubMed: 17704056). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed: 8170954). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed: 20176812).

Sep 1, 2024 · Different types of PTMs tend to have various effects on E2Fs. For example, ubiquitination can promote the degradation of E2Fs, whereas acetylation can maintain their stability. Phosphorylation and methylation can either activate or inhibit the activity of E2Fs.

E2F1 binds preferentially RB1 in a cell-cycle dependent manner (By similarity). It can mediate both cell proliferation and TP53/p53-dependent apoptosis (PubMed: 9674698). Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed: 11672531, PubMed: 20176812).

E2F proteins regulate the transcription of S phase cyclins and genes required for DNA replication, DNA repair, and apoptosis. The activity of E2F1, the archetypal and most heavily studied E2F family member, is tightly controlled by the DNA damage checkpoints to modulate cell cycle progression and initiate programmed cell death, when required.

Apr 1, 2015 · E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. Directly activates transcription of PEG10. Positively regulates transcription of RRP1B.

Oct 10, 2019 · Cyclin F activity regulates transcriptional control of target genes involved in replication and DNA damage repair (tiers 2+3) by controlling the levels of the transcription activators E2F1, E2F2, and E2F3a and the atypical transcription repressor E2F7.

Aug 20, 2015 · We set out to study how E2F1, a key controller of cell cycle, apoptosis, and DNA damage responses, functions in the developing and adult testis.

transcription factor E2F1 (human) Definition : A transcription factor E2F1 that is encoded in the genome of human. Short Label : hE2F1 : Category : organism-gene

PTM: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis. PTM: Acetylation stimulates DNA-binding. Enhanced under stress conditions such as DNA damage and inhibited by retinoblastoma protein RB1.

E2F1 is a transcription factor containing DNA-binding domains and can regulate the expressions of targeted proteins by binding on the promoters . E2F1 can also modulate cell cycle, cell apoptosis, differentiation and DNA repair [10,11].