Mar 28, 2025 · E2F1 (E2F Transcription Factor 1) is a Protein Coding gene. Diseases associated with E2F1 include Retinoblastoma and Squamous Cell Carcinoma . Among its related pathways are Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) …

Mar 28, 2025 · E2F2 (E2F Transcription Factor 2) is a Protein Coding gene. Diseases associated with E2F2 include Hematologic Cancer and Retinoblastoma. Among its related pathways are Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) and Cyclins and Cell Cycle Regulation.

Mar 28, 2025 · E2F3 (E2F Transcription Factor 3) is a Protein Coding gene. Diseases associated with E2F3 include Retinoblastoma and Glioma Susceptibility 1. Among its related pathways are Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) …

Mar 28, 2025 · E2F4 (E2F Transcription Factor 4) is a Protein Coding gene. Diseases associated with E2F4 include Colorectal Cancer and Retinoblastoma. Among its related pathways are Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) and G0 and Early G1.

Mar 28, 2025 · E2F5 (E2F Transcription Factor 5) is a Protein Coding gene. Diseases associated with E2F5 include Retinoblastoma and Uterine Corpus Endometrial Carcinoma. Among its related pathways are G0 and Early G1 and Gene expression (Transcription).

Mar 28, 2025 · E2F7 (E2F Transcription Factor 7) is a Protein Coding gene. Diseases associated with E2F7 include Gastric Cancer and Retinal Disease. Among its related pathways are Gene expression (Transcription) and TP53 Regulates Transcription of Cell Cycle Genes.

Mar 28, 2025 · E2F6 (E2F Transcription Factor 6) is a Protein Coding gene. Diseases associated with E2F6 include Ovarian Cancer and Retinoblastoma. Among its related pathways are Gene expression (Transcription) and Mitotic G1 phase and G1/S transition.

Mar 28, 2025 · E2F8 (E2F Transcription Factor 8) is a Protein Coding gene. Diseases associated with E2F8 include Retinal Disease. Among its related pathways are Gene expression (Transcription) and TP53 Regulates Transcription of Cell Cycle Genes.

Mar 30, 2025 · This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to ...

Mar 30, 2025 · The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription (PubMed:10499802).