May 3, 2019 · E2Fs also have roles beyond cell cycle regulation that when dysregulated contribute to cancer, including roles in apoptosis, metabolism and angiogenesis 18, 19. This …

Oct 2, 2002 · Recent studies demonstrate that E2F1 can induce both proliferation and apoptosis. E2F1-induced apoptosis occurs via multiple pathways, some of which induce stabilization and …

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In …

Currently, the best-characterized activity, especially at the hands of E2F1, in addition to its traditional role in cell cycle progression is its ability to induce apoptosis [19–22]. In some …

Nov 17, 2008 · For example, E2F1 can sensitize cells to apoptosis by inhibiting survival signals, in particular those mediated by the transcription factor NF- κ B or by Bcl-2 and its family member …

E2F transcription can lead to cell proliferation or apoptosis, indicating that E2Fs control opposing functions. In a similar manner, DNA double-strand breaks can signal to induce cell cycle arrest …

Here, these findings are highlighted in the context of the most recent follow-up studies that have used apoptotic E2F1 genes as new therapeutics or drug targets, thereby providing insight into …

Dec 1, 2009 · Given the frequent inactivation of p53 in human cancers, the E2F1-induced apoptosis pathway is rapidly gaining attention as a key mechanism to compensate the loss of …

Dec 20, 2007 · The cell cycle factor E2F-1 is known to regulate a variety of cellular processes including apoptosis. Previously we showed that disruption of Rb–E2F-1 complexes provoked …

More recent work has shown that E2F-1 regulates apoptosis as well as proliferation, in part by stabilizing the p53 tumor suppressor, an important mediator of apoptosis.