Structural basis of simultaneous recruitment of the transcriptional ...
Aug 8, 2011 · Chromatin occupancy studies also show that activation of gene expression by GATA1 almost invariably involves cooccupation at the relevant genomic loci by TAL1/SCL, …
Structure of the leukemia oncogene LMO2: implications for the …
Feb 17, 2011 · Loss-of-function studies in mouse and zebrafish have revealed critical functions for LMO2 in the establishment of primitive and definitive hematopoiesis during embryonic …
Expression of the leukemia oncogene Lmo2 is controlled by an …
Jun 4, 2009 · The combination of ChIP-chip and transgenic assays suggested differential regulation of Lmo2 elements with Ets factors acting on the endothelial promoter, while an …
The LIM-domain binding protein Ldb1 and its partner LMO2 act as ...
The Ldb1, LMO2, SCL/E12 Multiprotein Complex Recognizes the SCL E-Box DNA-Binding Motif. The potential involvement of Ldb1 in binding the SCL consensus E-box motif was evaluated by …
LIM-domain-only proteins in cancer - Nature Reviews Cancer
Jan 10, 2013 · LMO2 seems to function primarily through forming transcription factor complexes with TAL1 or LYL1, GATA proteins, LDB1, and E12 or E47 to regulate gene expression.
GATA2 and Lmo2 control angiogenesis and lymphangiogenesis …
GATA-binding protein 2 (GATA2) and LIM domain only 2 (Lmo2) form common transcription complexes during hematopoietic differentiation. Here we show that these two transcription …
SCL, GATA-2 and Lmo2 expression in neurogenesis
Aug 1, 2005 · In the present study, we describe the temporal and spatial pattern of the expression of SCL, GATA-2 and Lmo2 during early neurogenic periods in the embryonic chick brain. The …
The LIM-only protein Lmo2 is a bridging molecule assembling an ...
Jan 1, 2001 · We now show that in erythroid cells Lmo2 forms a novel DNA-binding complex, with GATA-1, TAL1 and E2A, and the recently identified LIM-binding protein Ldb1/NLI. This …
LMO2 (LIM domain only 2 (rhombotin-like 1))
Nov 1, 2007 · They form a transcriptional complex: LMO2 has no direct evidence in DNA binding capacity but could act as a bridging molecule bringing together different DNA binding factors …
Structural basis of simultaneous recruitment of the transcriptional ...
Aug 15, 2011 · Chromatin occupancy studies also show that activation of gene expression by GATA1 almost invariably involves cooccupation at the relevant genomic loci by TAL1/SCL, …