May 17, 1999 · We have explored the relationship between Axin and Dvl‐2, a member of the Dishevelled family of proteins that function upstream of GSK‐3β. Expression of Dvl‐2 activated …

We have explored the relationship between Axin and Dvl-2, a member of the Dishevelled family of proteins that function upstream of GSK-3beta. Expression of Dvl-2 activated TCF-dependent …

May 17, 1999 · We have explored the relationship between Axin and Dvl-2, a member of the Dishevelled family of proteins that function upstream of GSK-3beta. Expression of Dvl-2 …

Similar to Axin1, the binding partners of Axin2 are APC (aa 81–200), GSK3 (aa 372–413), β catenin (aa 414–476), and DVL (aa 761–843). So far, all mutations found in Axin2 are located …

Apr 2, 2025 · AXIN2 is a core component of the destruction complex in the canonical Wnt/β-catenin signaling pathway, ... Additionally, Frat1 interacts with Dishevelled (Dvl) and Axin to …

One explanation is that the total level of Axin-like protein (Axin plus Axin2) needs to be elevated in certain cells; Axin provides a basal level in all cells , while Axin2, which is induced by Wnt/β …

Upregulation of Dvl sustains Wnt/β-catenin signaling, whereas Dvl2 loss suppresses tumor development in the intestine of the APC-mutant mouse, suggesting Dvl2 may represent a …

Jul 15, 2007 · Using photobleaching experiments of GFP-tagged Dvl2 and axin to study the dynamics of their interaction, we found that the recruitment of axin-GFP by Dvl2 assemblies is …

Dishevelled (DVL) proteins serve as crucial regulators that transduce canonical Wnt signals to the GSK3β-destruction complex, resulting in the stabilization of β-catenin. Emerging evidence …

Sep 18, 2019 · Our study reveals a mechanism for regulating signaling pathways via the polymerization status of scaffold proteins and suggests a strategy for targeted colorectal …