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Changes in blood flow in the celiac artery, superior mesenteric artery, and pancreas in response to an intravenous injection of synthetic human gastric inhibitory polypeptide (GIP) were determined simultaneously and continuously in anesthetized dogs, using a transit-time ultrasonic flowmeter and a laser-Doppler flowmeter.

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Jul 5, 2013 · Gipg013 is a specific competitive antagonist with equally high potencies to mouse, rat, dog, and human GIP receptors with a Ki of 7 nm for the human GIPr. Gipg013 antagonizes the GIP receptor and inhibits GIP-induced insulin secretion in vitro and in vivo.

Jan 22, 2016 · In humans with meal- or food-induced hypercortisolemia, patients are born with a congenital defect that results in the aberrant expression of receptors for glucagon inhibitory peptide (GIP) on the adrenal gland.2 When stimulated by GIP, the adrenal glands in these patients produce cortisol.

Because of the differences in the data concerning the mechanism by which gastric inhibitory polypeptide (GIP) is secreted following fat ingestion, we were prompted to investigate the characteristics of the GIP response to the triacylglycerol components in normal dogs.

In the GIP-infused dogs the rise in plasma TG was significantly below that of the control animals [mean peak of 36 +/- 4 mg/dl vs. 82 +/- 18 mg/dl (P less than 0.05)]. It is concluded that GIP exerts an effect upon the removal of chylomicron TG from the blood.

Gastric inhibitory peptide GIP is a 42–amino acid peptide that has a dual action: (1) inhibiting gastric acid production and (2) stimulating insulin secretion. Hall and coworkers reported that plasma GIP concentrations were not altered during endurance exercise (42 km and 80 km).

Two major physiological roles for GIP have been established. An enterogastrone-like action in dog, in which it has been shown that physiological doses of the hormone will inhibit gastric acid secretion stimulated by histamine, gastrin or insulin hypoglycaemia (1) and...

May 1, 2004 · Glucose-dependent insulinotropic peptide (GIP) has been reported to have opposing effects on splanchnic blood flow. GIP infusion in dogs results in an increase in portal vein circulation but a drop in hepatic artery blood flow.