Transferrin receptor is necessary for development of erythrocytes …
Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes. Endosomal acidification leads to iron release, and iron is …
Frontiers | Divalent metal transporter 1 (DMT1) in the brain ...
Jun 8, 2015 · In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells. DMT1 locates to cellular …
The Roles of DMT1 in Inflammatory and Degenerative Diseases
Jan 7, 2025 · Based on available knowledge, this review described a full view of DMT1 and summarized the roles of DMT1 and DMT1-mediated iron metabolism in the onset and …
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice …
Feb 15, 2001 · Interestingly, in Trf hpx homozygotes, DMT1 expression was strongly induced in the villus brush border when compared to control animals. This suggests that DMT1 …
Transferrin receptor is necessary for development of ... - Nature
Apr 1, 1999 · Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity. Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo...
Divalent Metal Transporter 1 Regulates Iron-Mediated ROS
Oct 3, 2012 · Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1β induces divalent metal transporter 1 (DMT1) expression …
Deferoxamine-induced high expression of TfR1 and DMT1 …
May 31, 2019 · Results: In this study, we found that DFO treatment significantly increased the levels of iron uptake proteins, DMT1 and TfR1, in aggressive TNBCs. Moreover, both TfR1 …
Divalent metal transporter 1 (DMT1) regulation by Ndfip1
Sep 8, 2009 · Here, we show that DMT1 is regulated by Ndfip1 (Nedd4 family-interacting protein 1), an adaptor protein that recruits E3 ligases to ubiquitinate target proteins. Using human …
The Endolysosomal Transporter DMT1 is Required for Morphine …
We found endogenous DMT1 isoforms in the cytoplasm that colocalized with lysosomal-associated protein 1 (LAMP1), a marker of endolysosomes. Next, we blocked endogenous …
DMT1 Expression and Iron Levels at the Crossroads Between …
Jun 5, 2019 · The development of different neurodegenerative diseases is associated with alterations of the intracellular transport of iron and heavy metals, principally mediated by …