Frontiers | Divalent metal transporter 1 (DMT1) in the brain ...
Jun 8, 2015 · In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells. DMT1 locates to cellular …
The Roles of DMT1 in Inflammatory and Degenerative Diseases
Jan 7, 2025 · DMT1, a core iron transporter, is expressed in almost all cells and organs and altered in response to various conditions, whereas, there is few reviews focusing on DMT1 in …
H+-coupled divalent metal-ion transporter-1: Functional …
Divalent metal-ion transporter-1 (DMT1) is a widely-expressed, iron-preferring membrane transport protein. Animal models establish that DMT1 plays indispensable roles in intestinal …
DMT1 and iron transport - PubMed
DMT1 expression is regulated by iron through the translational and degradation pathways to ensure iron homeostasis. It is considered that mammalian iron transporters including DMT1 …
Hypoxia regulates the ferrous iron uptake and reactive oxygen …
Jul 28, 2010 · We identified a functional HRE at position −327 to −323 of the DMT1 exon1B promoter, which is necessary for stimulation of DMT1 gene by hypoxia.
Loss of divalent metal transporter 1 (DMT1) function promotes …
The divalent metal transporter 1 (DMT1) is a major iron transporter required for iron absorption and erythropoiesis. Loss of DMT1 function results in microcytic anemia. While iron plays an …
The Endolysosomal Transporter DMT1 is Required for Morphine …
We found endogenous DMT1 isoforms in the cytoplasm that colocalized with lysosomal-associated protein 1 (LAMP1), a marker of endolysosomes. Next, we blocked endogenous …
Divalent metal transporter 1 (DMT1) in the brain: implications …
Jun 8, 2015 · In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells. DMT1 locates to cellular …
Divalent Metal Transporter 1 Regulates Iron-Mediated ROS
Oct 3, 2012 · Through a combination of in vitro and in vivo studies, we show that the proinflammatory cytokine IL-1β induces divalent metal transporter 1 (DMT1) expression …
Natural resistance-associated macrophage protein 2 - Wikipedia
Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), [5] is a protein that in humans …