Oct 5, 2022 · We present evidence showing that the severe defects in endosome maturation in Mon1 -KO cells are attributable to Rab5 hyperactivation rather than to Rab7 inactivation. We …

Jan 23, 2018 · Taking advantage of mitochondrial RAB7-GAPs (TBC1D15 and TBC1D17) KO cells, we found RAB5 and RAB7A were associated to damaged mitochondria during Parkin …

May 27, 2021 · Here we found that AMPK positively regulates the activation of Rab5, a small GTPase which is involved in regulating Glut4 translocation, in both myoblasts and skeletal …

cells. In VAP DKO cells, labeling of intracellular vesicles was strikingly stronger, and this difference was abolished by expres-sion of VAPA or VAPB (Figure S1D). PI4P-positive …

Oct 31, 2023 · To test whether the Hybrid complexes have specific functions, we attempted to generate double KO (dKO) cells lacking two of the Rab-binding VPS genes, as the single KO …

Jul 14, 2016 · Confocal microscopy imaging of VAP DKO cells showing the presence of an endosomal Rab (Rab5-mRFP, bottom), a retromer subunits (YFP-VPS29, top left), and a trans …

RAB5C recruitment to damaged mitochondria was greatly enhanced in TBC1D15/17 DKO cells ( Figure 7 A). Another RAB5 variant RAB5B behaved similarly to RAB5C (Figure 7-figure …

We present evidence showing that the severe defects in endosome maturation in Mon1-KO cells are attributable to Rab5 hyperactivation rather than to Rab7 inactivation. We then identified …

Apr 26, 2021 · In this study, we revealed that Wdr45/45b double knockout (DKO) impairs autophagosome fusion with late endosomes/lysosomes in Neuro-2a (N2a) cells. WDR45 and …

Nov 28, 2022 · A significant decrease of the RAB5-GFP mean lifetime value (τ) was observed in cells expressing RAB5-GFP and mCherry-Cb5 (donor and acceptor) compared with cells …