DKK1, a negative regulator of Wnt signaling, is a target of the
Sep 20, 2004 · Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of …
Drug Discovery of DKK1 Inhibitors - PMC - PubMed Central (PMC)
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin signaling pathway, whose dysregulation is associated with multiple abnormal pathologies …
Dkk1 Controls Cell-Cell Interaction through Regulation of Non …
Dec 12, 2019 · Our results show that Dkk1 represses cell polarization and integrity of cell-cell adhesion, independently of its impact on β-catenin protein degradation. Concurrently, Dkk1 …
Function and biological roles of the Dickkopf family of Wnt
Dec 4, 2006 · Dickkopf (Dkk) genes comprise an evolutionary conserved small gene family of four members (Dkk1 - 4) and a unique Dkk3 -related gene, Dkkl1 (soggy). They encode secreted …
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin ...
May 26, 2002 · Wnt/β-catenin signalling is inhibited by the secreted protein Dickkopf1 (Dkk1), a member of a multigene family, which induces head formation in amphibian embryos 7. Dkk1 …
DKK1 promotes migration and invasion of non-small cell lung ... - PubMed
Mechanically, β-catenin plays a vital role in DKK1-induced non-small cell lung cancer cell migration and invasion, and DKK1 inhibits the phosphorylation of β-catenin, resulting in the …
Dkk1 Controls Cell-Cell Interaction through Regulation of Non …
Dec 16, 2019 · Our results show that Dkk1 represses cell polarization and integrity of cell-cell adhesion, independently of its impact on β-catenin protein degradation. Concurrently, Dkk1 …
DKK1 Activates the PI3K/AKT Pathway via CKAP4 to Balance the
Jun 14, 2024 · However, our study has revealed an intriguing phenomenon where Dickkopf-1 (DKK1), an inhibitor of Wnt/β-catenin signaling, promotes MSC migration at certain …
In this study, Johansson and colleagues show that Dkk1 controls cell migration, polarity, and adhesion independently of its known function in fate specification and modulation of Wnt/PCP …
Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the …
Overexpression of Dkk1 down-regulated the expression of c-Myc and cyclin D1, while silence down-regulated the expression of Atg8, beclin, and LC3, the results showed that cordycepin …