DKK1 is central to embryonic and adult bone development and bone health and disease, and has emerged as a central molecular player among various factors that promote bone metastases. DKK1 ensures proper skeletal development and homeostasis, LRP5-mediated DKK1 signaling is essential to maintain bone mass, and DKK1 has been implicated in genetic ...

Elevated levels of DKK1 in bone marrow, plasma and peripheral blood are associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [5] Due to the role of DKK1 in inflammation induced bone loss DKK1 is under investigation as target for therapeutic strategies in medicine and dentistry.

Jan 21, 2021 · Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has...

DKK1 may play a key role in the development of MBD by directly interrupting Wnt-regulated differentiation of osteoblasts, whereas blocking DKK1 activity in myelomatous bones reduces osteolytic bone resorption, increases bone formation, and helps control PCM growth.

The Wnt-signaling pathway is one of the most important pathways controlling bone metabolism and consequently the action of inhibitors of the pathway such as sclerostin and Dickkopf-related protein 1 (DKK1) have crucial roles in controlling bone formation and resorption.

Dickkopf-1 (DKK-1) has been considered a master regulator of bone remodeling. As precursors of osteoclasts (OCs), myeloid-derived suppressor cells (MDSCs) were previously shown to participate in the process of bone destruction in rheumatoid arthritis (RA).

Jan 15, 2009 · Preclinical studies have shown that neutralizing DKK1/Dkk1 and/or enhancing Wnt/β-catenin signaling may prove effective in treating bone pathologies. Here, we review the rapidly growing body of literature defining a pivotal role for DKK1 in bone health and disease.

Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM. Here, we investigated the functional role of Dkk1 in T1DM-induced bone loss in mice.

Oct 1, 2011 · Recent evidence suggests that Dickkopf-1 (DKK-1), a soluble inhibitor of the Wnt pathway, may be an active player in several critical aspects of bone biology (1, 2). The Wnt pathway was first described more than 20 years ago but its role in bone biology was only recently unraveled (3, 4).

Osteoblastic bone metastases are commonly detected in patients with advanced prostate cancer (PCa) and are associated with an increased mortality rate. Dickkopf-1 (DKK-1) antagonizes canonical WNT/β-catenin signaling and plays a complex role in bone metastases.