Principles of genetic circuit design - Nature Methods
Apr 29, 2014 · Cells navigate environments, communicate and build complex patterns by initiating gene expression in response to specific signals. Engineers seek to harness this capability to program cells to...
Synthetic biology: advancing the design of diverse genetic systems
Design and construction of a prototype CMY (Cyan-Magenta-Yellow) genetic circuit as a mutational readout device to measure evolutionary stability dynamics and determine design principles for robust synthetic systems.
Principles of Genetic Circuit Design - PMC - PubMed Central (PMC)
New biochemistries, tuning knobs, and troubleshooting methods are now converging for the sophisticated design and construction of genetic circuits. In these circuits, different classes of regulators can be used in a single circuit to fulfill specialized functions.
1. Introduction to Biological Circuit Design
May 29, 2020 · Genetic circuits control diverse biological behaviors. Our goals are twofold: Understand the principles that explain the organization of natural biological circuits (systems biology) and allow the design of novel synthetic circuits that implement new cellular behaviors (synthetic biology).
In design-ing genetic circuits, each of the connections in the cen-tral dogma (e.g., DNA to mRNA) represents a point where regulation can be implemented to achieve the desired behavior, such as a digital logic gate.
Genetic Circuit Design Principles - SpringerLink
Oct 1, 2021 · Section “Principles in Design and Construction of Genetic Circuits” covers the important considerations during the design and construction phases of genetic circuits, with a brief mention of reporter genes commonly used in the testing phase.
Designing Biological Circuits: From Principles to Applications
Mar 23, 2022 · Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first genetic circuits─the repressilator and the toggle switch─were designed and implemented, many advances have been made in this area of research.
This review describes new tools that aid the construction of genetic circuits. We show how circuit dynamics can be influenced by the choice of regulators and changed with expression
Genetic circuit design is a well-studied problem in synthetic biology. Ever since the first genetic circuits—the repressilator and the toggle switch—were designed and implemented, many advances have been made in this area of research.
Toward predictable universal genetic circuit design - Gao - 2024 ...
Apr 30, 2024 · These findings pave the way to predictably design and tune a universal genetic circuit with complex functions and hold vast potential for realizing design automation of universal circuits in diverse hosts.