Benzodiazepines (BZD, BDZ, BZs), colloquially known as "benzos", are a class of CNS depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures.

The Benzodiazepines (BDZs) are a group of components that receive their name because in their chemical structure have a benzene ring joined to other seven-members heterocyclic ring called Diazepine (Figure 1). Figure 1. Benzodiazepines basic structure. There is a wide range of medicines that belong to these types of substances.

Diazepine is a seven-membered heterocyclic compound with two nitrogen atoms (e.g., in ring positions 1 and 2). Types include: 1,2-Diazepine; 1,3-Diazepine; 1,4-Diazepine. Benzodiazepines, a class of commonly used medications whose structure contains a 1,4-diazepine ring

However, since all of the important benzodiazepines contain a aryl substituent ring C) and a 1, 4-diazepine ring, the term has come to mean the aryl-1,4-benzodiazepines. There are several useful benzodiazepines available: chlordiazepoxide (Librium) and diazapam (Valium).

Midazolam is a water-soluble, short-acting benzodiazepine. Its chemical configuration confers a pH-dependent ring phenomenon. At pH 4, the diazepine ring opens, and a highly stable water-soluble compound results. At physiologic pH values, the ring closes and thereby increases the drug lipophilic activity.

The diazepine ring of all molecules adopts a bent boat-like conformation, with two possible isoenergetic conformers, which are mirror images of one another. The two conformers have opposite chirality and are named P (plus) or M (minus) according to the sign of the (O=)C–C(H 2)–N=C torsion angle (see the inset to Figure 7). All three ...

Diazepine | C5H6N2 | CID 166734 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Aug 30, 2022 · Benzodiazepine, a potent pharmacophore of crucial biodiversity for drug discovery, is the heterocyclic molecule of focus in this study. The psychoactive substance benzodiazepine, 1 and its derivatives are bicyclic heterocyclic compounds having a benzene ring fused to a seven-membered ring.

All benzodiazepines have a benzene ring attached to a diazepine ring. In the green circles are benzene rings and in the red circle is a diazepine ring, with the whole 1,4-benzodiazepine system being in the blue ring (the 1 and 4 denote the position of the nitrogen atoms in the ring

In concert with this, the development of new synthetic approaches to the 1,4-diazepine ring system and their further elaboration have provided access to a broad range of functionalized derivatives that have contributed to advances in understanding the underlying principles of structure and reactivity.