Desmin is a protein that in humans is encoded by the DES gene. [5][6] Desmin is a muscle-specific, type III intermediate filament [7] that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture. [8][9]

Desmin is a protein made by muscle cells. Non-cancerous and cancerous tumours made up of muscle cells also produce desmin.

Desmin stain is a 52kDa cytoplasmic intermediate filament present in muscle and endothelial cells; expressed in neoplasms with myogenic differentiation Menu Chapters By Subspecialty

Nov 15, 2004 · Desmin is a muscle-specific protein and a key subunit of the intermediate filament in cardiac, skeletal and smooth muscles. Desmin filaments are mainly located at the periphery of Z-disk of striated muscles and at the dense bodies of smooth muscle cells, and they have been postulated to play a criti …

The DES gene provides instructions for making a protein called desmin. Desmin is found in heart (cardiac) muscle and muscles used for movement (skeletal muscle). Within muscle fibers, desmin proteins are important to help maintain the structure of sarcomeres, which are necessary for muscles to tense (contract).

Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis.

Desmin is a class-III IF protein and is one of the major IF proteins in cardiac and skeletal muscle. Mutations in the desmin gene cause desmin myopathy that presents as both muscular dystrophy and cardiomyopathy (Dalakas et al. 2000, Goldfarb et al. 1998).

Intermediate filaments were first described in muscle in 1968, and desmin was biochemically identified about 10 years afterwards. Its importance grew after the identification of desminopathies and desmin mutations that cause mostly cardiopathies. ...

Oct 31, 2014 · Desmin is a muscle-specific type III intermediate filament essential for proper muscular structure and function. In human, mutations affecting desmin expression or promoting its aggregation lead to skeletal (desmin-related myopathies), or cardiac (desmin-related cardiomyopathy) phenotypes, or both.

Dec 11, 2021 · Desmin is a muscle-specific protein.It is the main intermediate filament protein and a key component in the cytoskeletal network of muscle cells e.g. in the myocardium, where it is ampler than in skeletal muscle or smooth muscle. It interacts with other proteins to support the myofibrils at the level of the Z-discs or of the intercalated discs and has a role in mechanochemical signal ...