Mar 30, 2025 · RIGI (RNA Sensor RIG-I) is a Protein Coding gene. Diseases associated with RIGI include Singleton-Merten Syndrome 2 and Singleton-Merten Dysplasia. Among its related pathways are DDX58/IFIH1-mediated induction of interferon-alpha/beta and SARS-CoV-2 Infection. An important paralog of this gene is IFIH1.

DDX58 and IFIH1 are members of the retinoic acid inducible-like receptors (RLR) and recognize exogenous RNA from many viruses, including coronavirus, Zika virus, and rubella. 7,9-11 DDX58 signals downstream through the mitochondrial activating complex, ultimately activating TANK-binding kinase (TBK1). 8 In turn, downstream phosphorylation of ...

Three RLRs recognize viral RNA. While DDX58 (also known as RIG-I) senses 5′-phosphorylated RNA, IFIH1 (MDA5) recognizes long dsRNA. DHX58 (LGP2) facilitates viral RNA recognition by DDX58 and IFIH1 and enhances RLR-dependent IFN induction .

Nov 24, 2023 · TBK1, IRF3 and IκBα phosphorylation were all reduced at 2 and 4 h post infection (h p.i.), confirming that HOIP is required for the complete activation of both IRF3 and NF-κB pathways ...

Nov 19, 2022 · RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of RIG-I occurring in patients with colon cancer.

DDX58/RIG-I, is a critical pattern recognition receptor for viral RNA, which plays an essential role in antiviral immunity. Its posttranslational modifications and stability are tightly regulated to mediate the moderate production of type I IFN to maintain the immune homeostasis.

Mar 13, 2020 · Activating mutations in the genes encoding RIG-I and MDA5 (DDX58 and IFIH1, respectively) have been identified in some patients with Singleton–Merten syndrome or Aicardi–Goutières syndrome 67 ...

Apr 9, 2022 · Silencing the m6A demethylase alkB homolog 5, RNA demethylase (ALKBH5) suppresses tumor progression in vitro and in vivo. m6A-RNA immunoprecipitation sequencing reveals that ALKBH5 downregulates the m6A modification of DDX58 mRNA.

May 9, 2021 · To uncover the mechanism DDX58 uses to reduce lipotoxicity, we focused on characterizing PA-induced inflammation and autophagic responses in HepG2 cells treated with a DDX58 agonist. We found that TBK1 phosphorylation correlated with SQSTM1 phosphorylation, followed by an increase in total levels of SQSTM1, and a subsequent decrease in DDX58 ...

Apr 9, 2022 · ChIRP-MS demonstrates that HNRNPC binds to the m6A sites of DDX58 mRNA to promote its maturation. ALKBH5 overexpression inhibits RIG-I-mediated IFNα secretion through the IKKε/TBK1/IRF3 pathway. The number of tumor-infiltrating lymphocytes in C3H immunocompetent mice is reduced by ALKBH5 overexpression and restored by …