Jul 12, 2019 · DEAD-box helicases (DDXs) regulate RNA processing and metabolism by unwinding short double-stranded (ds) RNAs. Sharing a helicase core composed of two RecA-like domains (D1D2), DDXs function...

Aug 30, 2024 · In particular, the DExD/H-box (DDX) helicase family possesses a conserved catalytic core that binds structural features rather than specific sequences in RNA targets. DDXs have critical roles in all aspects of RNA metabolism including ribosome biogenesis, translation, RNA export, and RNA stability.

The DDX family of RNA helicases are multifunctional proteins with ubiquitous functions in RNA metabolism such as pre-mRNA splicing, miRNA processing, RNA transport, and ribosome biogenesis [1].

Human DDX helicases belong to the DEAD-box protein family, which is the largest family of the superfamily 2 (SF2) helicases (Byrd and Raney, 2012). They share a highly conserved helicase core consisting of two RecA-like domains (D1 and D2) connected via a flexible linker region (Hilbert et al., 2009).

Mar 1, 2021 · DEAD-box (DDX, RH) is a type of ATPase activity-dependent RNA helicases, belongs to SF2, which is the largest helicase family in the six RNA helicase (RHs) superfamilies (SF1-SF6) (Gorbalenya and Koonin, 1993).

Apr 25, 2024 · In this study, we use solution nuclear magnetic resonance (NMR) spectroscopy to characterize the interaction of human DDX3X, a member of the DDX family, with various RNA ligands.

Apr 25, 2023 · Our study reveals protein kinase stimulation by nucleotide exchange as important for kinase regulation and as a generic function of DDX proteins. DEAD box (DDX) proteins are a large family of RNA-dependent adenosine triphosphatases (ATPases) that play key roles in a vast array of biological processes (1).

Nov 15, 2022 · DEAD (DDX)/ DEAH (DHX)-box family of putative RNA helicases are enzymes belonging to the SF2 helicase superfamily. These enzymes are essential for RNA metabolism and integrity of RNA machinery by conserving the helicase cores while unwinding RNA helices.

May 26, 2023 · The RNA helicase DEAD box (DDX) family belongs to superfamily 2, the largest family of RNA lyases. The DDX family is characterized by a consensus Asp-Glu-Ala-Asp (DEAD) motif, and the human genome encodes 37 DDX members [10].

We have now adopted DDX and DHX symbols to denote DEAD- and DEAH-box families, respectively. Members of human DDX and DHX families of putative RNA helicases play roles in differentiation and carcinogenesis.