020080 STOCK Slc6a3 tm1(cre)Xz /J The DAT-cre "knock-in" allele has a nuclear-localized Cre recombinase inserted just upstream of the first coding ATG of the dopamine transporter gene ( …

These mice may be useful for studying gene function in dopaminergic neurons, such as drug addiction, Parkinson's disease and Attention Deficit-Hyperactivity Disorder …

Oct 8, 2024 · DAT-Cre transgenic mouse lines have been particularly useful in resolving the diverse functions of the brain’s dopamine (DA) systems. Here we report DAT-Cre-driven …

Oct 11, 2019 · For the DA system, we characterized the DAT-Cre 41, TH-Cre 42 and PITX3-Cre 43 mouse lines which express Cre under control of the dopamine transporter (DAT), tyrosine …

Cre-mediated excision of the floxed region results in a knock-out of <em>Mcu</em> in dopaminergic neurons, useful in studies of Parkinson's disease (PD).

Feb 8, 2021 · Heterozygous mice that express Cre-recombinase under the dopamine transporter promoter (DAT-Cre knock in mice, or KI) are widely used for targeting midbrain dopamine …

Dat-Cre. 遗传背景：C57BL/6 . 品系类型：靶向突变 . 相关基因：Slc6a3. 应用领域： 使用 Dat-Cre 小鼠，科研工作者可特异性标记多巴胺能神经元，进而通过光遗传学、化学遗传学等操控手段 …

Cre重组酶活性早在胚胎第15天就被观察到，并与内源性基因表达在成年多巴胺能细胞群(黑质(SN)和腹侧被盖区(VTA)，以及大脑后野)共定位。 在成人嗅球中检测到较低的Cre重组酶活 …

Mar 15, 2024 · By taking advantage of DAT-Cre-tdTomato mice, we sought to deepen our understanding of DA neurons and their putative subtypes in the ENS. We conducted …

Oct 31, 2019 · The study demonstrates that DAT-Cre transgenic mice, beyond their usefulness in recombination of floxed alleles in DA neurons, could be implemented as tools to achieve …