Perhaps the most widely used mouse model of colitis employs dextran sodium sulfate (DSS), a chemical colitogen with anticoagulant properties, to induce disease. DSS is a water-soluble, negatively charged sulfated polysaccharide with a highly variable molecular weight ranging from 5 …

Feb 4, 2014 · Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed.

The most widely used mouse model of colitis employs dextran sodium sulfate (DSS), a chemical colitogen with anticoagulant properties, to induce epithelial damage. The DSS colitis model lends itself to IBD research due to its rapidity, simplicity, reproducibility and controllability.

Mar 2, 2020 · In the present study, we combined a validated UC mouse model (dextran sulfate sodium, DSS) and a well-controlled inhalation exposure design with disease-specific endpoints and system-wide...

Dextran sodium sulfate (DSS)-induced colitis mouse model is used for research of inflammatory bowel disease. The aim of this study was to establish the adequate conditions for DSS mice model, and to find useful tool to measure inflammation. The 2.5% DSS was administered to six male C57BL/6 mice and 4% DSS to eight mice at 5 or 9 weeks of age.

Jun 1, 2017 · In our experience, DSS concentrations of 2–3% (wt/vol) in the drinking water for 7 d induce marked colitis in C57BL/6 mice, with low mortality rates (as compared with 2.5–5% in Balb/c mice).

Feb 4, 2014 · Among various chemically induced colitis models, the dextran sulfate sodium (DSS)-induced colitis model is widely used because of its simplicity and many similarities with human ulcerative colitis. This model has both advantages and disadvantages that must be considered when employed.

Mar 26, 2025 · Therefore, DSS is commonly used to induce ulcerative colitis, study its pathogenesis and evaluate the effects of drug treatment . In this study, 3% DSS was used to construct a mouse model of ulcerative colitis to observe the effect of the G7 strain on DSS-induced ulcerative colitis in mice.

Mar 11, 2025 · DSS-induced inflammatory bowel disease model was established in Piezo1 td/Tdt or Piezo1 fl/fl and Piezo1 LysM male mice. Additionally, bone marrow-derived macrophages from Piezo1 fl/fl and Piezo1 LysM male mice were isolated to elucidate the downstream targets of Piezo1 and the associated underlying molecular mechanisms.

Oct 16, 2021 · Dextran sulfate sodium (DSS) replicates ulcerative colitis (UC)-like colitis in murine models. However, the microbial characteristics of DSS-triggered colitis require further clarification. To analyze the changes in gut microbiota associated with DSS-induced acute and chronic colitis.