DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK …
Dec 1, 2010 · In this study, we used alogliptin, a specific inhibitor of DPP 4/CD26, to study the effect of DPP-4/CD26 on the activation of the extracellular signal-regulated kinase (ERK) that …
- Author: Nga N. Ta, Yanchun Li, Corinne A. Schuyler, Maria F. Lopes-Virella, Maria F. Lopes-Virella, Yan Huan...
- Publish Year: 2010
Dipeptidyl peptidase-4 inhibitors have adverse effects for the ...
Recently, DPP-4 inhibitors (DPP4i) are reported to have several immunologic effects beyond glycemic control. DPP4i seem to have anti-inflammatory effects in patients with type 2 …
DPP-4 Inhibitor Attenuates Toxic Effects of Indoxyl Sulfate on …
DPP-4 inhibitor restored IS-induced deactivations of AKT and ERK and inhibited activation of NF-κB in IS-treated HK-2 cells. Moreover, DPP-4 inhibitor could also attenuate IS-induced up …
The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors
Jul 21, 2014 · Diabetes and hyperglycemia increase the DPP-4 protein level and enzymatic activity in blood and tissues. In addition, multiple other functions of DPP-4 suggest that DPP-4 …
- Author: Na-Hyung Kim, Taeyang Yu, Dae Ho Lee
- DOI: 10.1155/2014/368703
- Publish Year: 2014
- Publication: Biomed Res Int. 2014; 2014: 368703.
Soluble DPP-4 up-regulates toll-like receptors and …
We investigated the pro-inflammatory actions of sDPP-4 and the anti-inflammatory effects of DPP-4 inhibition, using vildagliptin, as an enzymatic inhibitor, and mannose-6-phosphate (M6P) as a competitive binding inhibitor.
Dipeptidyl Peptidase‐4 Inhibitor Anagliptin Prevents Intracranial ...
Jun 19, 2017 · DPP‐4 (dipeptidyl peptidase‐4) inhibitors have anti‐inflammatory effects, including suppressing macrophage infiltration, in various inflammatory models. We examined whether a …
The dipeptidyl peptidase‐4 (DPP‐4) inhibitor …
Jul 31, 2018 · DPP-4 inhibits β-adrenoreceptor agonist-induced Ucp1 expression via the activation of ERK signalling. It has been reported that sDPP-4 affects …
- Author: Kenichiro Takeda, Honami Sawazaki, Haruya Takahashi, Yu Sheng Yeh, Huei Fen Jheng, Wataru Nomura, Ta...
- Cited By: 13
- Publish Year: 2018
- Published: 31 July 2018
DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK
In this study, we used alogliptin, a specific inhibitor of DPP 4/CD26, to study the effect of DPP-4/CD26 on the activation of the extracellular signal-regulated kinase (ERK) that plays a critical …
Ugonin P inhibits lung cancer motility by suppressing DPP-4 …
Nov 1, 2023 · We determined that ugonin P suppresses the DPP-4-dependent migration and invasion of lung cancer cells by downregulating the RAF/MEK/ERK signalling pathway and …
DPP-4 (CD26) inhibitor alogliptin inhibits TLR4 …
The finding from the present study that alogliptin is a potent inhibitor for LPS-stimulated ERK phosphorylation in U937 cells suggests that the inhibitors of CD26/DPP-4 activity may modulate inflammatory responses in macrophages.
