A detailed method is described for measuring DPOAEs to assess cochlear function in mice. Recommendations are given for the required equipment and instructions are presented for setting up a DPOAE system. Also, a protocol is outlined for measuring DPOAEs in mice and troubleshooting tips are provided.

DPOAE iso-input functions demonstrate that young mice lacking Ceacam16 retain near-normal hearing consistent with their WT-like ABR thresholds . Our previous data also indicated that 70% of null mutants generate SOAEs with an average frequency (± SD) of 23.8 ± 3.7 kHz.

Distortion product otoacoustic emissions (DPOAEs) reflect outer hair cell integrity and cochlear function. When used appropriately in the audiology clinic, they are an effective diagnostic tool and can detect hearing loss with accuracy.

Feb 27, 2025 · Distortion product otoacoustic emissions (DPOAE) are generated in the cochlea when the outer hair cells amplify and propagate particular sounds along the basilar membrane in response to two tones separated by a fixed ratio and played from …

Medial olivocochlear (MOC) efferent feedback is suggested to protect the ear from acoustic injury and to increase its ability to discriminate sounds against a noisy background. We investigated whether type II spiral ganglion neurons participate in the contralateral suppression of …

Cochlear function was evaluated in a longitudinal study of 28 inbred strains of mice at 3 and 5 mo of age using measures of distortion product otoacoustic emissions (DPOAEs) in response to a federal initiative to develop rapid mouse phenotyping methodologies.

Feb 2, 2024 · Cochlear vibrations and DPOAEs were compared in adult (3–7 week old) wild-type CBA/CaJ mice of either sex. Mice were anesthetized (80–100 mg/kg ketamine, 5–10 mg/kg xylazine) and placed on a heating pad to maintain body temperature at 38° C, with supplemental anesthetics given to maintain areflexia.

Oct 1, 1997 · One of the earliest histopathological changes associated with age-related hearing loss appears to be the disruption of outer hair cells (OHCs). To evaluate age-related changes in OHC function, distortion product otoacoustic emissions (DPOAEs) were recorded in the young and aging C57BL/6J mouse.

Distortion product otoacoustic emissions (DPOAEs) have been used to examine the development of hearing in the rat and gerbil. However, no reports of DPOAE measurement from the onset of hearing in mice are available.

Jul 18, 2023 · Ceacam16 −/− Mice. DPOAE iso-input functions demonstrate that young mice lacking Ceacam16 retain near-normal hearing consistent with their WT-like ABR thresholds . Our previous data also indicated that 70% of null mutants generate SOAEs with an average frequency (± SD) of 23.8 ± 3.7 kHz.