DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in …
Oct 19, 2019 · This study aimed at characterizing two pharmacological NADPH oxidase inhibitors, the newly described GSK2795039 and the widely used diphenyleneiodonium (DPI), focusing …
Diphenyleneiodonium, an NAD(P)H oxidase inhibitor, also potently ...
Dec 18, 1998 · Diphenyleneiodonium (DPI) has frequently been used to inhibit reactive oxygen species (ROS) production mediated by flavoenzymes, particularly NAD(P)H oxidase. This …
Effect of Diphenyleneiodonium Chloride on Intracellular Reactive …
Our data suggested a combination of a membrane potential sensitive fluorescent dye, tetramethylrhodamine methyl ester (TMRM), and a ROS-sensitive dye, CM-H2DCFDA, …
A closer look into NADPH oxidase inhibitors: Validation and insight ...
May 1, 2020 · DPI is demonstrated to engage the heme and the flavin cofactors of NOXs. VAS2870 and VAS3947 are covalent bona-fide NOX inhibitors. A conserved active-site …
Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium …
Our results have demonstrated for the first time that downregulation of ROS level by treatment of cancer cells with an inhibitor of flavin—containing enzymes—DPI, leads to prolonged growth …
Diphenyleneiodonium Inhibits the Cell Redox Metabolism and …
Diphenyleneiodonium (DPI) and the structurally related compound diphenyliodonium (DIP) are widely used as inhibitors of flavoenzymes, particularly NADPH oxidase. Here we report further …
NADPH oxidase 2 inhibitor diphenyleneiodonium enhances ROS …
Jul 17, 2023 · In our study, DPI effectively inhibited ROS production by macrophages upon PMA or E. coli stimulation. Although other chemical inhibitors have similar effects on ROS …
DPI induces mitochondrial superoxide-mediated apoptosis
Feb 15, 2003 · In the present study, we showed that the flavoprotein inhibitor diphenyleneiodonium could induce mitochondrial reactive oxygen species (ROS) production …
Effect of Diphenyleneiodonium Chloride on Intracellular Reactive …
Dec 23, 2020 · The aim of this study was to investigate the effect of DPI on ROS metabolism and mitochondrial function in human amniotic membrane mesenchymal stromal cells (hAMSCs), …
An ultralow dose of the NADPH oxidase inhibitor …
Proposed model showing how an ultralow dose of DPI attenuates the progression of colitis-associated colorectal cancer. ROS is a major stimulant that activates macrophages into pro …
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