In biochemistry, intercalation is the insertion of molecules between the planar bases of deoxyribonucleic acid (DNA). This process is used as a method for analyzing DNA and it is …

Mar 14, 2025 · DNA intercalation occurs when molecules insert between base pairs of the DNA double helix, disrupting normal cellular processes. This mechanism is central to both …

Jun 18, 2015 · DNA intercalators are widely used as fluorescent probes to visualize DNA and DNA transactions in vivo and in vitro. It is well known that they perturb DNA structure and …

Intercalating agents are hydrophobic heterocyclic ring molecules that resemble the ring structure of base pairs, and include ethidium bromide, acridine orange, and actinomycin D. Insertion of …

Jun 21, 2024 · DNA intercalators are valuable tools for studying DNA-protein interactions and the structural dynamics of DNA. By binding to specific regions of DNA, intercalators can help …

DNA intercalators include aromatic heterocyclic compounds of various chemical classes with profound biological activities. The flat molecules of these ligands intercalate between base …

Dec 5, 2016 · DNA intercalation represents an invasive, yet reversible, mode of DNA-ligand binding. These essential features of DNA intercalation allow a wide range of precisely …

Mar 3, 2014 · Progresses in classical DNA intercalators over the last five years are reported. Related biological and biophysical assays are screened. Docking and molecular modeling …

DNA-binding metallo-intercalators are positively charged, planar, polycyclic, aromatic compounds that unwind the DNA double helix and insert themselves between DNA base pairs. [1]

Intercalation is a special binding mode where the planar aromatic moiety of a small molecule is inserted between a pair of base pairs, causing structural changes in the DNA and leading to its …