The DNA index (DI) is a prognostic factor in childhood acute lymphoblastic leukemia (ALL). The accuracy of DI measurement is important for treatment stratification: hyperdiploidy with DI > or = 1.16 is predictive of favorable prognosis whereas hypodiploidy is associated with poor prognosis.

The Combined DNA Index System (CODIS) is the United States national DNA database created and maintained by the Federal Bureau of Investigation.

The DNA content of a tumour may be expressed as the DNA index (DI) defined as the ratio between the DNA content of a tumour cell and that of a normal diploid cell. In clinical samples, chicken or trout erythrocytes are sometimes added to the sample to act as markers so that the ploidy of the sample can be more easily determined.

Nov 29, 2018 · DNA Index (DI) quantifies the DNA from leukemic blast by flow cytometry and has been correlated to the number of chromosomes. Our aim was to demonstrate the prognostic value of DI for minimal residual disease in childhood B-ALL.

If the DNA index is more than 1, the cancer cells have a higher-than-normal amount of DNA or extra chromosomes. The DNA index may be used to help plan treatment and estimate prognosis for some types of cancer, such as leukemia and neuroblastoma. Also called DNA ploidy.

DNA index (DI) is a well-established method for detection of high hyperdiploidy. The MLPA telomere kit identifies specific gain or loss of individual chromosomes and is suitable for screening for whole chromosome numerical changes 11,12.

DNA content is the most frequently measured entity of the cell. Analysis of DNA content reveals cell ploidy, provides information on cell position in the cell cycle and also allows one to estimate frequency of apoptotic cells that are characterized by fractional DNA content.

Jul 15, 2021 · Background: This study was aimed to evaluate the value of DNA index (DI) among pediatric acute lymphoblastic leukemia (ALL) treated on Children's Oncology Group (COG) protocols between 2000 and 2015. Methods: Retrospective study were analysis among pediatric ALL patients from the TARGET dataset.

Jul 28, 2023 · The DNA Index (DI) by flow cytometry method is considered more sensitive than karyotyping, because it can analyze large numbers of cells and detect aneuploid clones that represent only 2–3% of the cell population studied [4,5].

Sep 1, 2009 · The DNA index (DI) is a prognostic factor in childhood acute lymphoblastic leukemia (ALL). The accuracy of DI measurement is important for treatment stratification: hyperdiploidy...