In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the development of cancerous cells, or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure. They are especially useful in quantifying an organism's exposure to a carcinogen. [1] .

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body …

Scientific investigations have revealed that the majority of cancer causing chemicals, or chemical carcinogens, act through “genotoxic” or DNA damaging mechanisms, which involve covalent binding of the chemical to DNA (DNA adduct formation).

This chapter describes what is known about mechanisms and rates of DNA-adduct formation and removal, the significance of the adducts position on the DNA, and the correlation of of adducts of certain specific compounds with toxic effects.

A variety of DNA damaging agents can induce DNA damage, which becomes substrate for specific DNA repair pathways. Upper panel shows representative DNA damaging agents: errors from replication, spontaneous base deamination, alkylating agents, toxins, oxidative agents, ionizing radiation, UV radiation, crosslinking agents, aromatic compounds and ...

Aug 1, 2004 · Two studies have shown that increases in DNA-adduct levels are associated with cancer risk in humans. By analogy to experiments in animal models, administration of chemopreventive agents that...

Jan 3, 2025 · DNA adducts are a form of DNA damage caused by covalent attachment of a chemical moiety to DNA. Adducts that are not removed by the cell can cause mutations that may give rise...

Mar 12, 2025 · Explore how cells detect and repair DNA damage, the role of regulatory proteins, and the impact of these processes on genomic stability and cancer development.

In molecular genetics, a DNA adduct is a piece of DNA covalently bonded to a (cancer-causing) chemical. This process could be the start of a cancerous cell or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure (La et al., 1996).

Jan 18, 2019 · Two major nucleotide excision repair pathways, transcription-coupled repair (TCR) and global repair (GR), are well known to remove cisplatin-induced DNA adducts. TCR acts on the transcribed...