DM1 (also known as Steinert's disease) is the most prevalent form of the condition and generally the most severe. This form affects at least 1 in 2,300 people worldwide or 140,000 people in …

Sep 17, 1999 · Myotonic dystrophy type 1 (DM1) is a multisystem disorder that affects skeletal and smooth muscle as well as the eye, heart, endocrine system, and central nervous system. …

Myotonic Dystrophy Type 1 (DM1) is a rare neuromuscular disease that affects multiple organ systems, with symptoms ranging from myotonia (an inability for muscles to relax after flexing) …

Patients diagnosed with DM1 have multiple sets of DNA bases repeats in their genome (known as the CTG repeats). The CTG repeat size in adult onset is generally in the range of 50 to 1,000. …

Neuropathological findings in DM1 can be classified as follows: (1) protein and nucleotide deposits; (2) changes in neurons and glial cells; and (3) white matter alterations. Most findings …

Mar 1, 2023 · Twenty candidate drugs are in current preclinical and clinical phases in DM1. Three new interventional first-in-human clinical trials got underway during 2021–2022. New clinical …

Oct 29, 2024 · People with Myotonic Dystrophy Type 1 (DM1), the most common adult-onset form of muscular dystrophy, progressively lose muscle mass and strength in their lower legs, …

Myotonic dystrophy type 1 (DM1) is an underrecognized, progressive and often fatal neuromuscular disease with no approved therapies. DM1 is estimated to affect an estimated …

Congenital DM1 is characterized by hypotonia and severe generalized weakness at birth, often with respiratory insufficiency and early death; intellectual disability is common. …

Mar 30, 2025 · DM1-AS (DM1 Locus Antisense RNA) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with DM1-AS include Myotonic Dystrophy 1 and …