DDX5/DDX17 are coreguulators of p53, and DDX5 selectively regulates p53 mediation of growth arrest or apoptosis; DDX5 positively regulates the expression of p53 by inhibiting Δ133p53. In …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …

Jan 1, 2019 · DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in …

Jan 23, 2012 · In this work, we report that ddx5 and ddx17 have a dual role in the control of the pro-migratory NFAT5 transcription factor. First, ddx5 and ddx17 act as transcriptional …

We identify an important role for DDX5 in G1-to-S phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA Polymerase II to E2F …

Here, we show that the DEAD box RNA helicase 5 (DDX5) is overexpressed in alveolar RMS cells and that its depletion and pharmacological inhibition decrease FP-RMS viability and slow …

Aug 13, 2008 · Here we show that p68 unwinds the stem-loop IDX-rasISS1 structure and prevents binding of hnRNP H to IDX-rasISS1. We also found that p68 alters the dynamic …

the multiple functions of DDX5 make it both a superior independent oncogenic biomarker and target for targeted cancer therapy. In this article, we will summarize the relevant studies on …

Jul 7, 2022 · P68 RNA helicase regulates the alternative splicing of the important proto-oncogene H-Ras, and numerous studies have shown that p68 RNA helicase is probably involved in …

Aug 3, 2022 · DDX5 is involved in the selective splicing of H-Ras proto-oncogenes. H-Ras can be selectively spliced into two proteins, p21 H-Ras and p19 H-Ras. DDX5 produces the oncogene …