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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Multiple functions of the DEAD-box RNA helicase, …
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the …
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cell.com
Long Noncoding RNA NHEG1 Drives β-Catenin Transactivation and ...
researchgate.net
A scheme showing how DDX5 regulates actin cytoskeleton via miR-182 ...
frontiersin.org
Frontiers | DDX5 and DDX17—multifaceted proteins in the regulation of ...
wires.onlinelibrary.wiley.com
The DDX5/Dbp2 subfamily of DEAD‐box RNA helicases - Xing - 2019 - WIREs ...
frontiersin.org
Frontiers | DDX5 and DDX17—multifaceted proteins in the regulation of ...
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PubMed
https://pubmed.ncbi.nlm.nih.gov
DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating ...
Here we present evidence to show that, by interacting with autophagic receptor p62, DDX5 promotes autophagy and suppresses tumorigenesis. DDX5 inversely correlated with …
- Author: Hao Zhang, Yanqiu Zhang, Xiaoyun Zhu, Chen Chen, Chao Zhang, Yuanzheng Xia, Yucheng Zhao, Ourania An...
- Publish Year: 2019
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Selection of DDX5 as a novel internal control for Q-RT-PCR from ...
Sixty-six Affymetrix microarray slides using lung adenocarcinoma tissue RNAs were analyzed by a statistical re-sampling method in order to detect genes with minimal variation in gene …
Studies of DDX5 PKM2
PubMed
DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1
In hepatocellular carcinoma (HCC), dysregulated expression of DDX5 (DEAD box protein 5) and impaired autophagy have been reported separately. However, the relationship between them has not been explored. Here we present evidence to show that, by interacting with autophagic receptor p62, DDX5 promote...
Author: Hao Zhang
Published: 2019/3
Keywords: National In…
ScienceDirect
Review Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies
The DEAD-box RNA helicase DDX5 is a member of a family of highly conserved proteins involved in gene-expression regulation and ATP-dependent RNA helicase activities. Recently, it has been reported to be aberrantly expressed in many tumors, and is linked to the regulation of many cancer-related pathw...
Published: 2019/01/01
Cited By: 0
Keywords: DDX5; tum…
PubMed
Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 a superior oncogenic biomarker and target for targeted cancer therapy
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types. Studies over the years significantly exp...
Author: Fengzhi Li
Published: 2021/10/15
Keywords: DDX5; DE…
ScienceDirect
The DEAD-box RNA helicase DDX5 (p68) and β-catenin: The crucial regulators of FOXM1 gene expression in arbitrating colorectal cancer
Forkhead box M1 (FOXM1), a vital member of the Forkhead box family of transcription factors, helps in mediating oncogenesis. However, limited knowledge exists regarding the mechanistic insights into the FOXM1 gene regulation. DDX5 (p68), an archetypal member of the DEAD-box family of RNA helicases, ...
Published: 2023/06/01
Cited By: 0
Keywords: β-Catenin; …
ScienceDirect
PI3K/AKT/mTOR pathway-related long non-coding RNAs: roles and mechanisms in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide with high prevalence and lethality. The oncogenic phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is a classic dysregulated pathway involved in the pathogenesis of HCC. However,...
Published: 2020/10/01
Cited By: 0
Keywords: 4EBP1 4E-…
PubMed
DDX5: an expectable treater for viral infection- a literature review
Background and objective: DEAD-box protein (DDX)5 plays important roles in multiple aspects of cellular processes that require modulating RNA structure. Alongside the canonical role of DDX5 in RNA metabolism, many reports have shown that DDX5 influences viral infection by directly interacting with v...
Author: Minghui Hu
Published: 2022/6
Keywords: DEAD-box …
EMBO Press
https://www.embopress.org › doi › full
DDX5 inhibits inflammation by modulating m6A levels …
Jan 5, 2024 · DDX5 serves as a molecular switch to regulate inflammation during bacterial infection. DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, thereby triggering their degradation and reducing …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Role and therapeutic potential of DEAD-box RNA helicase family in ...
Additionally, DDX39B directly bound to PKM2 to increased its stability by competitively suppressing STUB1-mediated PKM2 ubiquitination and degradation, and then accelerated the …
Springer
https://link.springer.com › article
DEAD-box RNA helicases in the multistep process of tumor
Sep 22, 2024 · Researchers also reported a direct protein‒protein interaction between DDX39B and PKM2 in colorectal cancer that was independent of the DDX39B helicase activity center. …
People also ask
What is DDX5 (P68)?
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types.
Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5
pmc.ncbi.nlm.nih.gov
Does DDX5 interact with p62?
We found that DDX5 bound to p62 and interfered with p62/TRAF6 (tumor necrosis factor receptor-associated factor 6) interaction. Further findings revealed that the N-terminal domain of DDX5, involved in the interaction with p62, was sufficient to induce autophagy independent of its RNA binding and helicase activity.
DEAD Box Protein 5 Inhibits Liver Tumorigenesis by
pubmed.ncbi.nlm.nih.gov
What is DEAD box helicase 5 (DDX5)?
Dead-box helicase 5 (DDX5) is a member of this family. Experimental depletion of DDX5 inhibits proliferation of AML cells and induces apoptosis by promoting the production of ROS 9.
DDX5-targeting fully human monoclonal autoantibody inhibits
nature.com
Is DDX5 a cancer biomarker?
Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types. Studies over the years significantly expanded our understanding of the functional diversity of DDX5 in various cancer types and extended our knowledge of its Mechanism of Action (MOA).
Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5
pmc.ncbi.nlm.nih.gov
Does DDX5 suppress acute myeloid leukemia?
DDX5 has been recognized to be a novel target to suppress acute myeloid leukemia (AML). However, the role of DDX5 remains elusive in APL. Here a DDX5-targeting fully human monoclonal autoantibody named after 2F5 was prepared. It is demonstrated that 2F5 selectively inhibited APL cell proliferation without toxicity to normal neutrophil and tissues.
DDX5-targeting fully human monoclonal autoantibody inhibits
nature.com
Why is DDX5 important?
In human malignancies, many studies have detected the overexpression of DDX5 and confirmed its involvement in tumorigenesis, progression, invasion, proliferation, differentiation and metastasis. Its expression also correlates with the regulation of pathways that are critical in cancer development and progression.
Roles of DDX5 in the tumorigenesis, proliferation, differentiation
sciencedirect.com
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CancerIndex
http://www.cancerindex.org › geneweb
DDX5 | Cancer Genetics Web - CancerIndex
Aug 30, 2019 · In these cells, we also observed a higher PKM2/PKM1 ratio, which was not detected in the Panc-1 gemcitabine-resistant counterpart compared to parental Panc-1 cells, …
- Aliases: p68, HLR1, G17P1, HUMP68
- Location: 17q23.3
- Gene: DDX5; DEAD-box helicase 5
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Roles of DDX5 in the tumorigenesis, proliferation, differentiation ...
Jan 1, 2019 · DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in …
Nature
https://www.nature.com › articles
DDX5-targeting fully human monoclonal autoantibody inhibits ...
Jul 20, 2020 · Here a DDX5-targeting fully human monoclonal autoantibody named after 2F5 was prepared. It is demonstrated that 2F5 selectively inhibited APL cell proliferation without toxicity …
Nature
https://www.nature.com › articles
Pyruvate kinase M2 regulates homologous recombination …
Oct 8, 2018 · Here, we uncover an unexpected mechanism through which pyruvate kinase M2 (PKM2), the highly expressed PK isoform in cancer cells and a master regulator of cancer …
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Multiple functions of the DEAD-box RNA helicase, …

Images of DDX5 PKM2

DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating ...

Selection of DDX5 as a novel internal control for Q-RT-PCR from ...

DDX5 inhibits inflammation by modulating m6A levels …

Role and therapeutic potential of DEAD-box RNA helicase family in ...

DEAD-box RNA helicases in the multistep process of tumor

Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5

DEAD Box Protein 5 Inhibits Liver Tumorigenesis by

DDX5-targeting fully human monoclonal autoantibody inhibits

Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5

DDX5-targeting fully human monoclonal autoantibody inhibits

Roles of DDX5 in the tumorigenesis, proliferation, differentiation

DDX5 | Cancer Genetics Web - CancerIndex

Roles of DDX5 in the tumorigenesis, proliferation, differentiation ...

DDX5-targeting fully human monoclonal autoantibody inhibits ...

Pyruvate kinase M2 regulates homologous recombination …

Related searches for DDX5 PKM2

Related searches for DDX5 PKM2