DDX5/DDX17 are coreguulators of p53, and DDX5 selectively regulates p53 mediation of growth arrest or apoptosis; DDX5 positively regulates the expression of p53 by inhibiting Δ133p53. In …

Taken together, our findings indicate that DDX5 is a key p53-independent target of the ARF tumor suppressor and is a novel non-oncogene participant in ribosome biogenesis. The role of ARF …

DDX5 enhanced E2F1-mediated cell death, not only in parental HFFs, but also in those transduced with DNp53s. These results strongly suggest that DDX5 functions in a p53 …

Jul 7, 2013 · The RNA helicase p68 (DDX5) is an established co-activator of the p53 tumour suppressor that itself plays a pivotal role in orchestrating the cellular response to DNA …

Nov 1, 2011 · Taken together, our findings indicate that DDX5 is a key p53-independent target of the ARF tumor suppressor and is a novel non-oncogene participant in ribosome biogenesis.

Jul 18, 2013 · In the present study, we show that, while p68 is critical for p53-mediated transactivation of the cell-cycle arrest gene p21(WAF1/CIP1), it is dispensable for induction of …

Remarkably, knockdown of p53 or circASCC3 further promoted R-loop accumulation, while overexpression of DDX5 partially restored the R-loop levels (Fig. 7D and SI Appendix, Fig. …

Aug 19, 2023 · There is increasing evidence indicating the significant role of DDX5 (also called p68), acting as a master regulator and a potential biomarker and target, in tumorigenesis, …

Dec 10, 2024 · DDX5 enhanced E2F1-mediated cell death, not only in parental HFFs, but also in those transduced with DNp53s. These results strongly suggest that DDX5 functions in a p53 …

May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …