DDX5 plays essential transcriptional and post-transcriptional roles …
May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …
- Author: Julien M. D. Legrand, Julien M. D. Legrand, Ai-Leen Chan, Ai-Leen Chan, Hue M. La, Hue M. La, Fernan...
- Publish Year: 2019
Functions of DEAD box RNA helicases DDX5 and DDX17 in …
DDX5 and DDX17 share a highly homologous ATPase domain (90% homology in human proteins), and ATP binding and hydrolysis are necessary to catalyze the unwinding of local …
Role of the DEAD-box RNA helicase DDX5 (p68) in …
Aug 19, 2023 · In this review, we discuss the multifaceted functions of DDX5 in DNA repair in cancer, immune suppression, oncogenic metabolic rewiring, virus infection promotion, and negative impact on the human microbiome (microbiota).
Multiple functions of the DEAD-box RNA helicase, …
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the …
Ubiquitination regulates autophagy in cancer: simple …
Oct 31, 2024 · Expression of DEAD box protein 5 (DDX5) has been found to reduce the p62/TRAF6-mediated lysine 63-linked ubiquitination of the mammalian target of rapamycin …
DDX5 and its associated lncRNA - Nature
Dec 16, 2015 · Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORÎłt partner that coordinates transcription of selective T H 17 genes, and is required for T H 17-mediated inflammatory...
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DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or …
DDX5 directly interacts with O-linked N-acetylglucosamine transferase (OGT) which stabilizes the DDX5 protein through O-GlcNAcylation, resulting in high expression levels. DDX5, in turn, …
DDX5 helicase resolves G-quadruplex and is involved …
Sep 23, 2019 · The DDX5 interaction with the MYC promoter and DDX5-mediated MYC activation is inhibited by G4-interactive small molecules. Our results uncover a function of DDX5 in resolving DNA and RNA G4s and suggest a molecular …
DDX5-targeting fully human monoclonal autoantibody inhibits ...
Jul 20, 2020 · Here a DDX5-targeting fully human monoclonal autoantibody named after 2F5 was prepared. It is demonstrated that 2F5 selectively inhibited APL cell proliferation without toxicity …
DDX5 - an overview | ScienceDirect Topics
DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in cancer …
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