Functions of DEAD box RNA helicases DDX5 and DDX17 in …
In both cases, Ddx5 is recruited to Myod and Runx2 responsive promoters, and it enhances their transcriptional activity. During myogenesis, one consequence is the induced expression of …
RNA Helicases DDX5 and DDX17 Dynamically …
Jun 26, 2014 · DDX5 and DDX17 cooperate with heterogeneous nuclear ribonucleoprotein (hnRNP) H/F to control splicing subprograms in epithelial cells and myoblasts. They help to initiate differentiation-specific transcription …
Multiple functions of the DEAD-box RNA helicase, …
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the …
- Studies of DDX5 MyoD
Entry - *180630 - DEAD-BOX HELICASE 5; DDX5 - OMIM
Aug 19, 2016 · By immunoprecipitation analysis, Caretti et al. (2006) found that p68, p72 (DDX17; 608469), and the noncoding RNA SRA (SRA1; 603819) associated with MYOD (MYOD1; …
DDX5 plays essential transcriptional and post-transcriptional roles …
Using an inducible knockout mouse model, we characterise an essential role for DDX5 in spermatogonial maintenance and show that Ddx5 is indispensable for male fertility. We …
Multi-talented DEAD-box proteins and potential tumor promoters: …
May 5, 2010 · P68 (DDX5) and p72 (DDX17) are members of the DEAD-box RNA helicase family. They can unwind double-stranded RNA and also contribute to the remodeling of …
- Author: Ralf Janknecht
- Publication: Am J Transl Res. 2010; 2(3): 223-234.
- Publish Year: 2010
- Published: 2010
- People also ask
Here, we show that the DEAD box RNA helicase 5 (DDX5) is overexpressed in alveolar RMS cells and that its depletion and pharmacological inhibition decrease FP-RMS viability and slow …
the multiple functions of DDX5 make it both a superior independent oncogenic biomarker and target for targeted cancer therapy. In this article, we will summarize the relevant studies on …
P68 RNA helicase as a molecular target for cancer therapy
Aug 24, 2014 · P68 (DDX5) is considered as a prototypic member of the DEAD-box family of RNA helicases. It was fortuitously discovered through a cross-reaction with an antibody against the …
Here, we uncovered a mechanism by which DDX5 and DDX17 cooperate with heterogeneous nuclear ribo-nucleoprotein (hnRNP) H/F splicing factors to define epithelial- and myoblast …
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