DDX5 plays essential transcriptional and post-transcriptional
May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …
DDX5 inhibits hyaline cartilage fibrosis and degradation in ...
May 17, 2024 · Targeted upregulation of DDX5 in mouse chondrocytes inhibits hyaline cartilage fibrosis and degradation via pre-mRNA splicing and G4 unwinding, a potential therapeutic …
DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 ...
Jan 5, 2024 · DDX5 serves as a molecular switch to regulate inflammation during bacterial infection. DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, …
DDX5 promotes esophageal squamous cell carcinoma growth …
Sep 17, 2024 · This study aimed to investigate the function of DEAD-box helicase 5 (DDX5) in ESCC progression and to identify a promising inhibitor of DDX5.
DDX5 mRNA-targeting antisense oligonucleotide as a new …
Feb 1, 2023 · An ASO selectively targeting DDX5 mRNAs (DDX5-ASO, WO2021099394A1, 2021) is developed and illustrated in its high efficiency in the downregulation of DDX5 …
RNA Helicase DDX5 Inhibits Reprogramming to ... - ScienceDirect
Apr 6, 2017 · Disrupting Ddx5 expression improves the efficiency of iPSC generation and impedes processing of miR-125b, leading to Rybp upregulation and suppression of lineage …
DDX5 directly interacts with METTL3. A: Co-IP of DDX5 and …
The immunoprecipitation (IP) data showed that DDX5 interacts with METTL3 and co-localizes with it in the cytoplasm and nucleus (Fig 2 A and 2B).
Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 ...
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …
AURKAIP1 actuates tumor progression through stabilizing DDX5
Dec 1, 2023 · AURKAIP1 directly interacted with and stabilized DDX5 protein by preventing ubiquitination and degradation, and DDX5 overexpression successfully reversed proliferation …
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 ... - The …
Feb 26, 2021 · An impaired BRCA2‐DDX5 interaction, as observed in cells expressing the breast cancer variant BRCA2‐T207A, reduces the association of DDX5 with DNA‐RNA hybrids, …