Feb 1, 2023 · DDX5 is critical for JAK2V617F mutant-induced cell proliferation and tumorigenesis. A point mutation (V617F) in the Janus kinase 2 (JAK2) gene results in the production of …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …

DUSP5 negatively regulates the ERK proliferation pathway; thus, overexpression of DDX5 observed in gliomas causes hyperactivation of ERK through downregulation of DUSP5, …

Circular RNA EGFR enhanced DDX5 expression via sponging miR-106a-5p to fulfill its oncogenic functions in CRC . DDX17 and DDX5 share the greatest homology among the DDX family …

Sep 7, 2022 · DDX5 was shown to function as a transcriptional coactivator of oestrogen receptor (ER), the androgen receptor (AR) and c-Myc [[29 - 31]], which have been implicated in the …

Furthermore, upregulating DUSP5 inhibited ERK phosphorylation, whereas downregulating DUSP5 rescued the level of ERK phosphorylation, indicating that DUSP5 might negatively …

Dec 21, 2021 · Phosphorylation-dependent sumoylation of DDX5 by PAK5 enhances formation of a DDX5/Drosha/DGCR8 complex, thus promoting miR-10b processing posttranscriptionally, …

DDX5 (p68) and DDX17 (p72) belong to the large family of evolutionarily conserved DEAD box RNA helicases (1). Because of their multiple molecular activities, these two proteins have …

Dec 16, 2015 · Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORγt partner that coordinates transcription of selective T H 17 genes, and is required for T H 17 …

Mar 26, 2024 · Collectively, these results revealed that DDX5 is a critical therapeutic target in CML and that FL118 is an effective candidate compound for the treatment of BCR-ABL …