DDX5 EZH2 - Search

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PubMed
https://pubmed.ncbi.nlm.nih.gov
LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex
Mar 4, 2021 · PRADX, mainly located in the nucleus of tumor cells, could bind to EZH2 protein via the 5' terminal sequence. Moreover, PRADX increased the trimethylation of H3K27 in the …
- Author: Yansheng Li, Xing Liu, Xiaoteng Cui, Yanli Tan, Qixue Wang, Yunfei Wang, Can Xu, Chuan Fang, Chunshe...
- Publish Year: 2021
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex …
Results: We found a lncRNA ENST00000449248.1 termed PRC2 and DDX5 associated lncRNA (PRADX) that is highly expressed in glioblastoma and colon adenocarcinoma cells and …
Cell Press
https://www.cell.com › cell-reports › fulltext
The RNA helicase DDX5 cooperates with EHMT2 to …
Aug 30, 2022 · We show that EHMT2 in turns regulates PAX3-FOXO1 activity in a methylation-dependent manner, thus sustaining FP-RMS myoblastic state. Together, our findings identify another survival-promoting loop in FP-RMS and …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
RNA Helicase DDX5 in Association With IFI16 and the Polycomb …
In HBV‐infected HepG2‐NTCP cells, the antiviral effect of interferon‐α was abrogated upon knockdown of DDX5 and EZH2, underscoring the crucial role of the DDX5 complex in …
Wiley Online Library
https://onlinelibrary.wiley.com › doi › full
RNA Helicase DDX5 in Association With IFI16 and the Polycomb …
Dec 16, 2024 · In HBV-infected HepG2-NTCP cells, the antiviral effect of interferon-α was abrogated upon knockdown of DDX5 and EZH2, underscoring the crucial role of the DDX5 …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Functions of DEAD box RNA helicases DDX5 and DDX17 in …
In hepatocytes, DDX5 also interacts with several subunits of the Polycomb-repressive complex 2 (PRC2), including the histone methyltransferase EZH2, which catalyzes the trimethylation of …
People also ask
How does pradx bind to EZH2?
PRADX, mainly located in the nucleus of tumor cells, could bind to EZH2 protein via the 5' terminal sequence. Moreover, PRADX increased the trimethylation of H3K27 in the UBXN1 gene promoter via PRC2/DDX5 complex recruitment and promoted NF-κB activity through UBXN1 suppression.
LncRNA PRADX-mediated recruitment of PRC2/DDX5 complex
pubmed.ncbi.nlm.nih.gov
Do DDX5 & DDX17 have helicase activity?
DDX5 and DDX17 are also important coregulators of various transcription factors, and they interact with a number of chromatin-associated factors (5). This may seem to conflict with their enzymatic activity, and it remains uncertain whether their helicase activity is required for this particular function.
Functions of DEAD box RNA helicases DDX5 and DDX17 in
pmc.ncbi.nlm.nih.gov
How does siRNA-mediated knockdown of DDX5 and EZH2 affect HBC-positive cells?
Importantly, siRNA-mediated knockdown of DDX5 or EZH2 abrogated the antiviral effect of IFN-α, leading to increased number of HBc-positive cells (Figure 7B), elevated levels of HBc protein (Figure 7C), and restoration of viral RNA expression in the presence of IFN-α (Figure 7D).
RNA Helicase DDX5 in Association With IFI16 and the Polycomb Repres…
onlinelibrary.wiley.com
How does DDX5 interact with Suz12?
Specifically, through interaction with SUZ12, a core PRC2 subunit, DDX5 stabilizes PRC2 and inhibits HBV biosynthesis . DDX5 is a DEAD box RNA helicase [12, 13] involved in various aspects of RNA biology in vivo, functioning by hydrolyzing ATP and mediating ATP-dependent RNA binding and remodeling .
RNA Helicase DDX5 in Association With IFI16 and the Polycomb Repres…
onlinelibrary.wiley.com
Does DDX5 heterodimerize with DDX17?
DDX5 heterodimerizes with DDX17, a related RNA helicase . Interestingly, helicase-active DDX17 binds the 5′ epsilon structure of HBV pgRNA inhibiting its encapsidation and acting as another host-restriction factor against HBV .
RNA Helicase DDX5 in Association With IFI16 and the Polycomb Repres…
onlinelibrary.wiley.com
What is the host-restriction function of DDX5?
Thus, the host-restriction function of DDX5 involves the assembly of an RNA-driven multicomponent complex comprised of IFI16 and PRC2, which orchestrates histone modifications silencing the HBV mini-chromosome.
RNA Helicase DDX5 in Association With IFI16 and the Polycomb Repres…
onlinelibrary.wiley.com
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › gene
LINC01116 long intergenic non-protein coding RNA 1116 [ (human)]
Dec 10, 2024 · LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1beta in glioma cell. Knockdown of LINC01116 inhibits cell migration …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
RNA helicase DEAD box protein 5 regulates Polycomb repressive …
Herein, we identified the RNA helicase, DEAD box protein 5 (DDX5), as a regulator of SUZ12 stability and PRC2‐mediated gene repression, acting by regulating RNA‐protein complexes …
CancerIndex
http://www.cancerindex.org › geneweb
DDX5 | Cancer Genetics Web - CancerIndex
The DEAD-box-protein DDX5 is an ATP-dependent RNA helicase that is frequently overexpressed in various cancers and acts as a transcriptional co-activator of several …
wiley.com
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RNA Helicase DDX5 in Association With IFI16 and the …
interferon‐α inhibited HBV rcccDNA transcription in a DDX5‐ and PRC2‐dependent manner. In HBV‐infected HepG2‐NTCP cells, the antiviral effect of interferon‐α was abrogated upon …
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