DDX5 deficiency drives non-canonical NF-ÎşB activation and NRF2 ...
Aug 9, 2024 · DDX5 inhibits Wnt/β-catenin signaling, preventing sorafenib-induced ferroptosis escape. Sorafenib/mTKIs reduce DDX5 expression, correlating with poor patient survival post …
DDX5 Regulates DNA Replication And Is Required For …
We identify an important role for DDX5 in G1-to-S phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA Polymerase II to E2F-regulated gene promoters.
Dysregulated gene-associated biomarkers for Alzheimer’s disease …
Jan 1, 2021 · DDX5 (p68), a critical component of the DEAD-box family, is encoded by the DDX5 gene located in the cell nucleus and shuttled between the nucleus and cytoplasm . DDX5 …
- Author: Min Li, Rongxin Geng, Chen Li, Fantao Meng, Hongwei Zhao, Jing Liu, Juanjuan Dai, Xuezhen Wang
- DOI: 10.1515/tnsci-2021-0009
- Publish Year: 2021
- Publication: Transl Neurosci. 2021 Jan 1; 12(1): 83-95.
- Studies of DDX5 BDNF
The Clothes Make the mRNA: Past and Present Trends in mRNP …
Some proteins were discovered via their ability to modulate expression of many mRNAs in a seemingly sequence-independent manner (e.g., FMRP, Staufen, and DDX5) or their …
DDX5 inhibits inflammation by modulating m6A levels …
Jan 5, 2024 · DDX5 serves as a molecular switch to regulate inflammation during bacterial infection. DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, thereby triggering their degradation and reducing …
Multiple functions of the DEAD-box RNA helicase, DDX5 (p68), make DDX5 ...
DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …
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DDX5 inhibits hyaline cartilage fibrosis and degradation in ...
May 17, 2024 · Targeted upregulation of DDX5 in mouse chondrocytes inhibits hyaline cartilage fibrosis and degradation via pre-mRNA splicing and G4 unwinding, a potential therapeutic …
the multiple functions of DDX5 make it both a superior independent oncogenic biomarker and target for targeted cancer therapy. In this article, we will summarize the relevant studies on …
DDX5 plays essential transcriptional and post-transcriptional roles …
May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in …
DDX5 Gene - GeneCards | DDX5 Protein | DDX5 Antibody
Mar 30, 2025 · DDX5 (DEAD-Box Helicase 5) is a Protein Coding gene. Diseases associated with DDX5 include Lung Cancer and Cartilage-Hair Hypoplasia. Among its related pathways are Processing of Capped Intron-Containing Pre …
