Sep 18, 2018 · Depletion of DDX5 could promote HCC cells growth. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that PI3K/Akt signaling …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a …

Jan 1, 2019 · Direct evidence of the role of DDX5 in the tumorigenesis of colon cancer is presented by recent studies reporting that the overexpression of DDX5 positively regulates the …

OGT-mediated O-GlcNAcylation stabilizes DDX5, activates the AKT/mTOR signaling pathway, and then accelerates the progression of colorectal cancer . Protein arginine methyltransferase …

Aug 19, 2023 · In this review, we discuss the multifaceted functions of DDX5 in DNA repair in cancer, immune suppression, oncogenic metabolic rewiring, virus infection promotion, and …

The increase in AKT transcription coupled with the depletion of the tumor suppressor FOXO3a (a downstream gene) accounts for the oncogenic role of DDX5 in colon cancer. In addition, …

Sep 18, 2018 · Depletion of DDX5 could promote HCC cells growth. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that PI3K/Akt signaling …

DDX5 deficiency orchestrates the activation of Wnt/β-catenin signaling in sorafenib-treated cells, thereby mediating escape from ferroptosis, a mechanism linked to drug resistance in cancer

Sep 18, 2018 · Depletion of DDX5 could promote HCC cells growth. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that PI3K/Akt signaling …

Here, we show that the DEAD box RNA helicase 5 (DDX5) is overexpressed in alveolar RMS cells and that its depletion and pharmacological inhibition decrease FP-RMS viability and slow …