Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene. [5] DEAD box proteins, characterized by the conserved motif Asp - Glu - Ala -Asp (DEAD), are putative RNA helicases.

Mar 30, 2025 · DDX5 (DEAD-Box Helicase 5) is a Protein Coding gene. Diseases associated with DDX5 include Lung Cancer and Cartilage-Hair Hypoplasia. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and SARS-CoV-2 …

DDX5 (p68) is a well-known multifunctional DEAD-box RNA helicase and a transcription cofactor. Since its initial discovery more than three decades ago, DDX5 is gradually recognized as a potential biomarker and target for the treatment of various cancer types.

May 23, 2019 · We demonstrate that DDX5 regulates appropriate splicing of key genes necessary for spermatogenesis. Moreover, DDX5 regulates expression of cell cycle genes in undifferentiated spermatogonia...

Dec 16, 2015 · Here we identify the RNA helicase DEAD-box protein 5 (DDX5) as a RORγt partner that coordinates transcription of selective T H 17 genes, and is required for T H 17-mediated inflammatory...

Jan 5, 2024 · DDX5 serves as a molecular switch to regulate inflammation during bacterial infection. DDX5 promotes the modification of TLR2/4 mRNA with N6-methyladenosine, thereby triggering their degradation and reducing subsequent NF-κB-dependent inflammatory responses.

Asp-Glu-Ala-Asp (DEAD)-box polypeptide 5 (DDX5), also called p68, is a prototypical member of the large ATP-dependent RNA helicases family and is known to participate in all aspects of RNA metabolism ranging from transcription to translation, RNA decay, and miRNA processing.

Gene ID: 1655, updated on 4-Jan-2025. This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors.

Feb 9, 2025 · HIV-1 Rev interacting protein, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 (DDX5), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with DDX5 is increased by RRE

DDX5 is implicated in tumorigenesis, proliferation, metastasis and differentiation in human malignancies. Cancer-related pathways modulated by DDX5 are potential targets in cancer diagnosis, prognosis and therapy. Pre-clinical studies of …