Nov 3, 2021 · Here we show that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity 5, instigates immune exclusion by promoting collagen fibre alignment. …

Nov 7, 2024 · We identified DDR1 as a promising target of immunotherapy resistance using a pooled in vivo CRISPR/sgRNA screening in microsatellite stable (MSS) CRC mouse models. …

Jan 13, 2022 · Bioinformatic analysis of human breast cancer samples confirmed an association between DDR1 expression level and CD8A expression or CD8 T cell signatures in human …

Discoidin domain receptor 1 (DDR1) is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of response to therapy. DDR1 contributes to …

Mar 22, 2024 · Results: Both DDR1 mRNA and protein expression levels were significantly correlated with all Immune Exclusion Scores (IESs) measured by the distribution of …

We demonstrated that DDR1 promotes colorectal tumor growth only in vivo. Mechanistically, DDR1 is a negative immunomodulator in colorectal cancer and is involved in low infiltration of …

We demonstrated that DDR1 promotes colorectal tumor growth only in vivo. Mechanistically, DDR1 is a negative immunomodulator in colorectal cancer and is involved in low infiltration of …

Here, we review new DDR1 functions in tumor dormancy following dissemination, immune exclusion and therapeutic resistance induced by stromal collagens deposition. We also …

High DDR1 expression is associated with CD8 exclusion across the full dataset of 14 tumor types (r=0.27, p = 0.0006), with strongest association in hormone receptor positive breast cancer (r …

We recently reported a novel role of discoidin domain-containing receptor 1 (DDR1) in promoting IE in breast cancer and validated its critical role in IE using neutralizing rabbit monoclonal …