Oct 7, 2022 · Therefore, it is crucial to decipher the detailed molecular events involved in DNA damage responses (DDRs) to DNA-damaging agents in cancer. The tumor suppressor p53 is active at the hub of...

The tumor suppressor p53 is active at the hub of the DDR. Researchers have identified an increasing number of genes regulated by p53 transcriptional functions that have been shown to be critical direct or indirect mediators of cell fate, cell cycle regulation, and DNA repair.

May 2, 2016 · Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA-damage-response (DDR) mechanisms.

This review elucidates the complex interplay between p53 and the different DDR pathways and highlights its central and essential role in detecting DNA damage, signaling and executing appropriate cellular responses. The dual nature of p53 as a tumor suppressor and a key player in the DDR further highlights its importance in cancer biology.

Dorset and Bak review the challenge of the p53-induced DNA damage response (DDR) following CRISPR-Cas9-based gene editing of hematopoietic stem and progenitor cells (HSPCs).

May 4, 2023 · The tumour suppressor p53 is a nuclear transcription factor with key roles during DNA damage to enable a variety of cellular responses including cell cycle arrest, apoptosis and DNA repair.

May 1, 2023 · The tumour suppressor p53 is activated following genotoxic stress and regulates the expression of target genes involved in the DNA damage response (DDR). The discovery that p53 isoforms alter the transcription of p53 target genes or p53 protein interactions unveiled an alternative DDR.

Apr 8, 2025 · The acetylation of p53 by CBP in response to DNA damage is commonly known to increase its transcriptional activity . ... As a result, DDR pathways involving bromodomain proteins play a critical role in safeguarding genome integrity and maintaining normal cellular functions . This may explain the observed restorative effect of the CBP ...

Mar 22, 2025 · Methods and results: In the present study, we investigated the regulatory role of p53 on the cellular recovery potential upon transient DNA damage. p53 deficiency promotes cell survival following transient DNA damage induction.

Erroneous repair of the DNA can lead to mutations and chromosomal aberrations that can alter the functions of tumor suppressor genes or oncogenes, thus causing cancer development. As a central tumor suppressor, p53 guards the genome by orchestrating a variety of DNA-damage-response (DDR) mechanisms.