May 1, 2020 · DNA double-strand breaks are the most lethal lesions induced by ionizing radiation and can trigger a series of cellular DNA damage responses (DDRs), including those helping …

The following DNA damage response (DDR) markers are used; BRCA1, BRCA2, RAD51, Ku70/Ku80, BARD, PARP1 (cleaved), PARP1 (non-cleaved), and P53 in addition to basal …

Cells respond to genotoxic stress through a series of complex protein pathways called DNA damage response (DDR). These monitoring mechanisms ensure the maintenance and the …

To achieve this, we need to be able to identify and test which patients have genetic biomarkers indicating underlying DDR defects, to allow patients to be matched to the right treatment.

Oct 1, 2021 · This review summarizes basic knowledge of DNA damage response (DDR) pathways, mechanisms of genomic instability induced by DDR alterations, impacts of DDR …

Corresponding changes in DDR marker expression are shown in (B, D, F, H, J), and the timing of xenograft sampling is indicated on the x-axes. Although all 3 markers are significantly …

Oct 11, 2023 · The DNA damage response (DDR) pathway regulates DNA repair and cell survival, and inactivating mutations in DDR genes can increase tumour mutational burden …

Mar 17, 2020 · The evolution of DNA repair proteomic biomarkers under treatment-related selection pressure is poorly described, hence our second aim was to describe changes in …

5 days ago · Results: We used 16 DDR marker genes to construct a predictive model. Furthermore, we established that the model had strong performance in both the training and …

The tumor suppressor P53-binding protein 1 (53BP1), as one of the main mediators of DDR, plays a pivotal role in orchestrating the choice of double-strand break (DSB) repair pathway and …