000671 DBA/2J DBA/2J is a widely used inbred strain. The strain characteristics include: susceptibility to audiogenic seizures; high-frequency hearing loss; comparative resistance to diet-induced atherosclerosis; development of progressive eye abnormalities that closely mimic human hereditary glaucoma; affinity for methamphetamine; and extreme ...

DBA/2J strain is distinct from the C57BL/6J strain and exhibits unique characteristics. This strain has high incidence of sterility. DBA/2J mice show a low susceptibility to developing atherosclerotic aortic lesions following 14 weeks on an atherogenic diet.

Dec 17, 2024 · View mouse strain DBA/2J : mutations, QTL, phenotypes, diseases, and references.

The inbred mouse strain DBA/2J is a recalcitrant strain that is used as a model of many human diseases, including glaucoma, deafness and schizophrenia. Here, we describe the generation of germ-line competent ES cell lines derived from DBA/2J mice.

Dec 4, 2018 · Mice of the DBA/2J strain are highly resistant to the development of atherosclerosis and vascular lesions, even after an extended period on an atherogenic (high fat and cholesterol) diet. Lifespan is long for the female but short for the male, and breeding performance is …

Dec 31, 2010 · C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of ...

DBA/LiA differs from /1 and /2 at the Gpd1 locus, and is similar to DBA/2 at the Tla locus. Note that unfostered substrains carry the mammary tumour virus and have a high indicence of mammary tumours.

Jul 23, 2010 · We sequenced the genome of DBA/2J using SOLiD and Illumina high throughput short read protocols to generate a comprehensive set of ~5 million sequence variants segregating in the BXD family that ultimately cause developmental, anatomical, functional and behavioral differences among these 80+ strains.

The file contains all strain survey measured phenotypes where DBA/2J was tested, along with measured means and summary statistics. Field names are given in the first row. The file includes some measurement metadata fields as well as some fields related to strain means.

Jan 16, 2024 · 000671 DBA/2J DBA/2J is a widely used inbred strain. The strain characteristics include: susceptibility to audiogenic seizures; high-frequency hearing loss; comparative resistance to diet-induced atherosclerosis; development of progressive eye abnormalities that closely mimic human hereditary glaucoma; affinity for methamphetamine; and extreme ...